ReviewFrontiers in physiology2022
Are head-down tilt bedrest studies capturing the true nature of spaceflight-induced cognitive changes? A review.
Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Review
- A computational model for retinal haemodynamics under gravitational and postural variations.The Journal of physiology · 2026Article
- Brain displacement and nonlinear deformation following human spaceflight.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Neuromotor changes in postural control following bed rest.The Journal of physiology · 2026Review
- Neural changes in microgravity: Investigating the effects of aerospace environments.IBRO neuroscience reports · 2025Review
- Behavioral and multiomics analysis of 3D clinostat simulated microgravity effect in mice focusing on the central nervous system.Scientific reports · 2025Article
- Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance.Frontiers in neurology · 2025Article
- Alteration of vasopressin-aquaporin system in hindlimb unloading mice.Frontiers in physiology · 2025Article
- Effect of artificial gravity on neurocognitive performance during head-down tilt bedrest.NPJ microgravity · 2024Article
- Personality matters in extremely demanding environments: A bed rest performance study.Frontiers in psychology · 2024Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although a number of studies have examined cognitive functions in space, the reasons behind the observed changes described by space research and anecdotal reports have not yet been elucidated. A potential source of cognitive changes is the cephalad fluid shift in the body caused by the lack of hydrostatic pressure under microgravity. These alterations can be modeled under terrestrial conditions using ground-based studies, such as head-down tilt bedrest (HDBR). In this review, we compare the results of the space and HDBR cognitive research. Results for baseline and in-flight/in-HDBR comparisons, and for baseline and post-flight/post-HDBR comparisons are detailed regarding sensorimotor skills, time estimation, attention, psychomotor speed, memory, executive functions, reasoning, mathematical processing, and cognitive processing of emotional stimuli. Beyond behavioral performance, results regarding brain electrical activity during simulated and real microgravity environments are also discussed. Finally, we highlight the research gaps and suggest future directions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.