Evidence map›Paper›PMID 36582345›Full record

ArticleBioactive materials2023

Nanoengineered sonosensitive platelets for synergistically augmented sonodynamic tumor therapy by glutamine deprivation and cascading thrombosis.

Liqiang Zhou, Wei Feng, Yuhang Mao, Yu Chen, Xuanjun Zhang

Open access · goldAbstract read
In one paragraph

Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
  2. Engineering platelets as cancer therapeutics.Nature reviews. Clinical oncology · 2026
    Review
  3. Biomimetic Cell Membrane-Coated MOFs System for Targeted Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Article
  10. Sonodynamic biomimetic-nanomedicine fight cancers.Journal of nanobiotechnology · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Self-Assembled Aza-Boron-Dipyrromethene-Based HAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Liqiang ZhouMOE Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau, SAR, 999078, China.
Wei FengMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, China.
Yuhang MaoSchool of Medical Technology, Xi'an Medical College, Xi'an, 710021, Shanxi, China.
Yu ChenMaterdicine Lab, School of Life Sciences, Shanghai University, Shanghai, 200444, China.
Xuanjun ZhangMOE Frontiers Science Center for Precision Oncology, Faculty of Health Sciences, University of Macau, Macau, SAR, 999078, China.
Shanghai University · CNUniversity of Macau · MOXi'an Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ultrasound (US)-activated sonodynamic therapy (SDT) stands for a distinct antitumor modality because of its attractive characteristics including intriguing noninvasiveness, desirable safety, and high tissue penetration depth, which, unfortunately, suffers from compromised therapeutic efficacy due to cancer cell-inherent adaptive mechanisms, such as glutathione (GSH) neutralization response to reactive oxygen species (ROS), and glutamine addictive properties of tumors. In this work, we developed a biological sonosensitive platelet (PLT) pharmacytes for favoring US/GSH-responsive combinational therapeutic of glutamine deprivation and augmented SDT. The amino acid transporter SLC6A14 blockade agent α-methyl-

Indexed as

Amino acid starvationDrug deliveryGlutamine deprivationSonodynamic tumor therapySonosensitive platelets

Identifiers

PMID36582345
PMCPMC9761609
OpenAlexW4310929196

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.