ArticleBioactive materials2023
A sandwiched patch toward leakage-free and anti-postoperative tissue adhesion sealing of intestinal injuries.
Article in Bioactive materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Infection-targeted innovations in anastomotic leak management: endoscopic advances, antimicrobial biomaterials, and precision strategies.Annals of medicine · 2026Review
- Functionalized bio-patches for intra-abdominal applications.iScience · 2026Review
- Bioadhesive-Integrated 3D-Printed Multilayer Scaffolds Secure a Mechanically-Stable Osteoimmune Niche for Enhanced Bone Augmentation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hydrogel Adhesives for Gastrointestinal Perforation: Design Principles and Applications.Exploration (Beijing, China) · 2026Review
- Autonomous Polymer Frameworks for Sustainable Tissue-Interfaced Plastic Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Charge balance transition enabledBioactive materials · 2025Article
- A supramolecular hydrogel leveraging hierarchical multi-strength hydrogen-bonds hinged strategy achieving a striking adhesive-mechanical balance.Bioactive materials · 2025Article
- Light-Operated Transient Unilateral Adhesive Hydrogel for Comprehensive Prevention of Postoperative Adhesions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Stimuli-Responsive Hydrogel Adhesives for Wound Closure and Tissue Regeneration.Macromolecular bioscience · 2024Review
- Bioactive citrate-based polyurethane tissue adhesive for fast sealing and promoted wound healing.Regenerative biomaterials · 2024Article
- Double-layer adhesives for preventing anastomotic leakage and reducing post-surgical adhesion.Materials today. Bio · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ideal repair of intestinal injury requires a combination of leakage-free sealing and postoperative antiadhesion. However, neither conventional hand-sewn closures nor existing bioglues/patches can achieve such a combination. To this end, we develop a sandwiched patch composed of an inner adhesive and an outer antiadhesive layer that are topologically linked together through a reinforced interlayer. The inner adhesive layer tightly and instantly adheres to the wound sites via -NHS chemistry; the outer antiadhesive layer can inhibit cell and protein fouling based on the zwitterion structure; and the interlayer enhances the bulk resilience of the patch under excessive deformation. This complementary trilayer patch (TLP) possesses a unique combination of instant wet adhesion, high mechanical strength, and biological inertness. Both rat and pig models demonstrate that the sandwiched TLP can effectively seal intestinal injuries and inhibit undesired postoperative tissue adhesion. The study provides valuable insight into the design of multifunctional bioadhesives to enhance the treatment efficacy of intestinal injuries.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.