Evidence map›Paper›PMID 36581965›Full record

Observational studyBMJ open2022

Soluble CD146 in the detection and grading of intravascular and tissue congestion in patients with acute dyspnoea: analysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort.

Renata Juknevičienė, Justas Simonavičius, Aurimas Mikalauskas, Kamilė Čerlinskaitė-Bajorė, Mattia Arrigo, Vytautas Juknevičius, Irina Alitoit-Marrote, Denis Kablučko, Loreta Bagdonaitė, Dalius Vitkus and 8 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 4 countries.

Renata JuknevičienėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.ORCID 0000-0002-7321-2990
Justas SimonavičiusCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Aurimas MikalauskasCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Kamilė Čerlinskaitė-BajorėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Mattia ArrigoDepartment of Internal Medicine, Triemli Hospital Zurich, Zurich, Switzerland.
Vytautas JuknevičiusClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Irina Alitoit-MarroteCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Denis KablučkoCentre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Loreta BagdonaitėInstitute of Biomedical Science, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Dalius VitkusInstitute of Biomedical Science, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Mindaugas BalčiūnasClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Gitana ZuozienėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Jūratė BarysienėClinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Diana ŽaliaduonytėDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Kęstutis StašaitisDepartment of Emergency Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Aušra KavoliūnienėDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Alexandre Mebazaa *Department of Anesthesiology and Critical Care, Assistance Publique des Hopitaux de Paris, Paris, France.
Jelena Čelutkienė *Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania jelena.celutkiene@santa.lt.
Vilnius University · LTLithuanian University of Health Sciences · LTInserm · FRUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the potential of soluble cluster of differentiation 146 (sCD146) in the detection and grading of congestion in patients with acute dyspnoea.

designSubanalysis of the prospective observational Lithuanian Echocardiography Study of Dyspnoea in Acute Settings (LEDA) cohort.

settingTwo Lithuanian university centres.

participantsAdult patients with acute dyspnoea admitted to the emergency department.

methodsCongestion was assessed using clinical and sonographic parameters. All patients underwent sCD146 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) testing.

resultsThe median value of sCD146 concentration in the study cohort (n=437) was 405 (IQR 315-509) ng/mL. sCD146 was higher in patients with peripheral oedema than in those without (median (IQR) 472 (373-535) vs 400 (304-501) ng/mL, p=0.009) and with pulmonary rales than in those without (439 (335-528) vs 394 (296-484) ng/mL, p=0.001). We found a parallel increase of estimated right atrial pressure (eRAP) and sCD146 concentration: sCD146 was 337 (300-425), 404 (290-489) and 477 (363-572) ng/mL in patients with normal, moderately elevated and high eRAP, respectively (p=0.001). In patients with low NT-proBNP, high sCD146 distinguished a subgroup with a higher prevalence of oedema as compared with patients with low levels of both biomarkers (76.0% vs 41.0%, p=0.010). Moreover, high sCD146 indicated a higher prevalence of elevated eRAP, irrespective of NT-proBNP concentration (p<0.05).

conclusionsCD146 concentration reflects the degree of intravascular and tissue congestion assessed by clinical and echocardiographic indices, with this association maintained in patients with low NT-proBNP. Our data support the notion that NT-proBNP might represent heart stretch while sCD146 rather represents peripheral venous congestion.

Indexed as

EchocardiographyHeart FailureAdultBiomarkersCD146 AntigenDyspneaHumansLithuaniaNatriuretic Peptide, BrainPeptide FragmentsProspective StudiesBiomarkersCD146 AntigenNatriuretic Peptide, BrainPeptide FragmentsAdult cardiologyEchocardiographyHeart failureUltrasoundVASCULAR MEDICINE

Identifiers

PMID36581965
PMCPMC9438196
OpenAlexW4294052454

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.