Evidence map›Paper›PMID 36581937›Full record

ArticleTrials2022

Conservative versus surgical treatment of foot drop in peroneal nerve entrapment: rationale and design of a prospective, multi-centre, randomized parallel-group controlled trial.

Christophe Oosterbos, Sofie Rummens, Kris Bogaerts, Sophie Hoornaert, Frank Weyns, Annie Dubuisson, Robin Lemmens, Tom Theys

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04695834 (A Prospective, Multi-center, Randomized, Parallel-group Controlled Trial to Compare Conservative Versus Surgical Treatment of Foot Drop in Peroneal Nerve Entrapment.), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04695834 narecruitingnot on this map

A Prospective, Multi-center, Randomized, Parallel-group Controlled Trial to Compare Conservative Versus Surgical Treatment of Foot Drop in Peroneal Nerve Entrapment.

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2021 to 2028Enrolled182ConditionsPeroneal Nerve EntrapmentArmsNeurolysis peroneal nerve, Maximal physiotherapy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Christophe OosterbosResearch Group experimental Neurosurgery and Neuroanatomy and the Leuven Brain Institute, KU Leuven, Leuven, Belgium. christopheoosterbos@gmail.com.ORCID http://orcid.org/0000-0003-2142-9941
Sofie RummensDepartment of Physical Medicine and Rehabilitation, University Hospitals Leuven, Leuven, Belgium.
Kris BogaertsDepartment of public health and critical care, I-BioStat, KU Leuven, Belgium and I-BioStat, UHasselt, Hasselt, Belgium.
Sophie HoornaertResearch Group experimental Neurosurgery and Neuroanatomy and the Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Frank WeynsDepartment of Neurosurgery, Ziekenhuis Oost-Limburg, Genk, Belgium.
Annie DubuissonDepartment of Neurosurgery, University Hospitals Liège, Liège, Belgium.
Robin LemmensDepartment of Neurosciences, Experimental Neurology, KU Leuven - University of Leuven, Leuven, Belgium.
Tom TheysResearch Group experimental Neurosurgery and Neuroanatomy and the Leuven Brain Institute, KU Leuven, Leuven, Belgium.
VIB-KU Leuven Center for Brain & Disease Research · BEAllen Institute for Brain Science · USHasselt University · BENeuroelectronics Research Flanders · BEUniversity of Liège · BEZiekenhuis Oost-Limburg · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-quality evidence is lacking to support one treatment strategy over another in patients with foot drop due to peroneal nerve entrapment. This leads to strong variation in daily practice. METHODS/

designThe FOOTDROP (Follow-up and Outcome of Operative Treatment with Decompressive Release Of The Peroneal nerve) trial is a randomized, multi-centre study in which patients with peroneal nerve entrapment and persistent foot drop, despite initial conservative treatment, will be randomized 10 (± 4) weeks after onset between non-invasive treatment and surgical decompression. The primary endpoint is the difference in distance covered during the 6-min walk test between randomization and 9 months later. Time to recovery is the key secondary endpoint. Other secondary outcome measures encompass ankle dorsiflexion strength (MRC score and isometric dynamometry), gait assessment (10-m walk test, functional ambulation categories, Stanmore questionnaire), patient-reported outcome measures (EQ5D-5L), surgical complications, neurological deficits (sensory changes, motor scores for ankle eversion and hallux extension), health economic assessment (WPAI) and electrodiagnostic assessment. DISCUSSION: The results of this randomized trial may elucidate the role of surgical decompression of the peroneal nerve and aid in clinical decision-making.

trial registrationClinicalTrials.gov NCT04695834. Registered on 4 January 2021.

Indexed as

Peroneal NeuropathiesAnkleAnkle JointHumansMulticenter Studies as TopicParesisProspective StudiesRandomized Controlled Trials as TopicTreatment OutcomeConservative treatmentFoot dropNeurolysisPeroneal nerveProtocol designRandomized controlled trial

Identifiers

PMID36581937
PMCPMC9801603
OpenAlexW4313365212

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.