Evidence map›Paper›PMID 36581761›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2023

Adverse effects of COVID-19 pandemic on a multicenter randomized controlled trial.

Elie G Abu Jawdeh, Carl E Hunt, Eric Eichenwald, Michael J Corwin, Betty McEntire, Timothy Heeren, Lisa M Crowell, Christine Ikponmwonba, Ariana Saroufim, Stephen Kerr and 1 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Elie G Abu JawdehUniversity of Kentucky, Lexington, KY, USA. elie.abujawdeh@uky.edu.ORCID 0000-0003-4414-7007
Carl E HuntUniformed Services University, Bethesda, MD, USA.
Eric EichenwaldChildren's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
Michael J CorwinBoston University, Boston, MA, USA.
Betty McEntireAmerican SIDS Institute, Naples, FL, USA.
Timothy HeerenBoston University, Boston, MA, USA.
Lisa M CrowellBoston University, Boston, MA, USA.
Christine IkponmwonbaAmerican SIDS Institute, Naples, FL, USA.
Ariana SaroufimBoston University, Boston, MA, USA.
Stephen KerrBoston University, Boston, MA, USA.
ICAF Study Group

Funding

Kentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2M
Intermittent Hypoxia and Caffeine in Infants Born PretermR01HD089289 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI EICHENWALD, ERIC C, HUNT, CARL E. · 2017 to 2021
$3.5M
NCATS NIH HHS UL1 TR001998NICHD NIH HHS R01 HD089289
6 · The paper itself

Abstract

objectiveDescribe the effects of the COVID-19 pandemic on subject enrollment in a multicenter randomized controlled trial. STUDY

designWe assessed the number of eligible infants approached and consented for enrollment over five separate epochs including baseline, peak pandemic, and gradual but incomplete recovery.

resultThe pandemic had a major effect on ability to approach parents for consent. Parents approached dropped from 95.4% baseline to 13.1% in the peak pandemic epoch and has not recovered to baseline even in the just-completed post-pandemic epoch (84.9%). Despite the decrease in subjects approached, there was no significant change in the overall consent rate for the study

conclusionThe pandemic has significantly limited ability to approach parents of eligible infants for consent, with only partial recovery. Opportunities for interactions of investigators and study coordinators with parents continue to present challenges limiting full recovery.

Indexed as

COVID-19Drug-Related Side Effects and Adverse ReactionsHumansInfantPandemicsParents

Identifiers

PMID36581761
PMCPMC9798371

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.