ArticleNature biomedical engineering2023
Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues.
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Article in Nature biomedical engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44citing papers in PubMed
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44 citing papers in PubMed.
- Decellularized cardiac ECM: A tissue-specific bioactive platform for drug release and cell delivery.Journal of controlled release : official journal of the Controlled Release Society · 2026Review
- Myocardial infarction treatment with a composite hydrogel containing metformin-induced vesicles of adipose-derived stem cells.Materials today. Bio · 2026Article
- Tunable regional targeting of self-assembling peptide nanomaterials in acute myocardial infarction.Advanced nanobiomed research · 2026Article
- In situ self-assembled stimulus-responsive and conductive hydrogel modulate myocardial infarction inflammatory homeostasis via PPARα/NFκB signaling and enhance the therapeutic efficacy of hiPSC-CMs.Bioactive materials · 2026Article
- Review
- Decellularized Dental Pulp Matrix Hydrogel Promotes Functional Endodontic Regeneration In Situ.International endodontic journal · 2026Article
- Multi-Omics Profiling Reveals Immunomodulatory and Pro-Regenerative Effects of a Graphene Oxide-Collagen Scaffold in Massive Rotator Cuff Tears.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Adaptive intrathecal nanorobotics in mice and nonhuman primates for navigated CNS therapy.Science advances · 2026Article
- Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction.Advanced healthcare materials · 2026Article
- Comparison of Crosslinking Reagents and Their Impacts on Bone Derived ECM Hydrogels.Advanced healthcare materials · 2026Article
- Cardiac-Derived ECM Microspheres for Enhanced hiPSC-CMs Maturation.Advanced functional materials · 2026Article
- Cardiac reprogramming via transient overexpression of P-glycoprotein alleviates doxorubicin-induced cardiotoxicity in mice and pigs.Nature communications · 2026Article
- [Extracellular matrix materials and tissue regeneration and repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Bioengineered Cellular and Acellular Therapies for Ischemic Heart Disease in Clinically Relevant Models.Bioengineering (Basel, Switzerland) · 2026Review
- A bioactive heart-derived ECM hydrogel potentiates Astragaloside IV-mediated microvascular regeneration.Frontiers in bioengineering and biotechnology · 2026Article
- Regional and cell specific bioactivity of injectable extracellular matrix biomaterials in myocardial infarction.Nature communications · 2025Article
- An infusible decellularized extracellular matrix material binds to vasculature in infarcted myocardium and induces pro-reparative gene expression following acute myocardial infarction through inherent avidity and bioactive signaling.bioRxiv : the preprint server for biology · 2025Article
- Infusible Extracellular Matrix Biomaterial Enhances Cell-Specific Pro-Repair Responses Following Acute Myocardial Infarction.bioRxiv : the preprint server for biology · 2025Article
- Rapid Deep Vat Printing Using Photoclickable Collagen-Based Bioresins.Advanced healthcare materials · 2025Article
- An infusible extracellular matrix biomaterial improves survival in a model of severe systemic inflammation.NPJ Regenerative medicine · 2025Article
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Authors and funding
28 authors.
Martin T SpangShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Ryan MiddletonShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Miranda DiazShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Jervaughn HunterShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Joshua MesfinShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0003-1022-8175
Alison BankaDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-3731-4647
Holly SullivanShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Raymond WangShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Tori S LazersonShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Saumya BhatiaShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
James CorbittShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Gavin D'EliaShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Gerardo Sandoval-GomezShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Rebecca KandellShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Maria A VratsanosDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-8377-4113
Karthikeyan GnanasekaranDepartment of Chemistry, International Institute for Nanotechnology, Chemistry of Life Processes Institute, Simpson Querrey Institute, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-6635-0888
Takayuki KatoShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Sachiyo IgataDivision of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Colin LuoShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Kent G OsbornAnimal Care Program, University of California San Diego, La Jolla, CA, USA.
Nathan C GianneschiDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.ORCID 0000-0001-9945-5475
Omolola Eniola-AdefesoDepartment of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8728-6608
Pedro CabralesShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Ester J KwonShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
Francisco ContijochShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9616-3274
Ryan R ReevesDivision of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Anthony N DeMariaDivision of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Karen L ChristmanShu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA. christman@eng.ucsd.edu.ORCID 0000-0002-6179-898X
Funding
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MIntegrative Bioengineering of Heart, Vessels, and BloodT32HL105373 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHIEN, SHU, INTAGLIETTA, MARCOS · 2010 to 2019
$3.6MUCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3MExtracellular matrix hydrogels for treating ischemiaR01HL113468 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTMAN, KAREN L · 2012 to 2020
$3.1MInfusible Extracellular Matrix for Treating Myocardial InfarctionR01HL165232 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTMAN, KAREN L · 2022 to 2025
$2.9MCellular Biotechnology Training Program (CBTP) - Years 31-35T32GM145304 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Guizhi Zhu · 2022 to 2026
$2.6MDevelopment of PolyAspirin Particles for Therapeutic Intervention in ALI/ARDS via the Passive Restraint of Neutrophil FunctionR01HL145709 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SINGER, BENJAMIN HERSCHEL · 2020 to 2023
$1.6MNew infusible ECM hydrogel for treating acute myocardial infarctionR43HL150917 · NHLBI · VENTRIX, INC. · PI CHRISTMAN, KAREN L, KINSEY, ADAM M · 2020 to 2020
$792kInjectable Decellularized Myocardial Matrix Hydrogel Mitigates Negative Left Ventricular Remodeling in a Chronic Myocardial Infarction ModelF31HL152686 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIAZ, MIRANDA DANAE · 2020 to 2022
$117kEnzyme responsive nanoparticle delivery of a small molecule MMP inhibitor following acute myocardial infarctionF31HL152610 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SULLIVAN, HOLLY · 2020 to 2022
$117kInvestigating Whether Myocardial Matrix Therapy Induces New Cardiomyocyte Formation Following Myocardial InfarctionF31HL137347 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, RAYMOND M · 2017 to 2019
$112kInvestigation of a Right Ventricle Based Decellularized Extracellular Matrix Hydrogel and Cardiac Progenitor Cells as a Treatment for Right Ventricular Heart FailureF31HL158212 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HUNTER, JERVAUGHN D · 2022 to 2023
$63kNHLBI NIH HHS F31 HL137347NHLBI NIH HHS F31 HL152610NHLBI NIH HHS F31 HL152686NHLBI NIH HHS F31 HL158212NHLBI NIH HHS R01 HL113468NHLBI NIH HHS R01 HL145709NHLBI NIH HHS R01 HL165232NHLBI NIH HHS R25 HL145817NHLBI NIH HHS R43 HL150917NHLBI NIH HHS T32 HL007444NHLBI NIH HHS T32 HL105373NIGMS NIH HHS T32 GM145304
Abstract
Decellularized extracellular matrix in the form of patches and locally injected hydrogels has long been used as therapies in animal models of disease. Here we report the safety and feasibility of an intravascularly infused extracellular matrix as a biomaterial for the repair of tissue in animal models of acute myocardial infarction, traumatic brain injury and pulmonary arterial hypertension. The biomaterial consists of decellularized, enzymatically digested and fractionated ventricular myocardium, localizes to injured tissues by binding to leaky microvasculature, and is largely degraded in about 3 d. In rats and pigs with induced acute myocardial infarction followed by intracoronary infusion of the biomaterial, we observed substantially reduced left ventricular volumes and improved wall-motion scores, as well as differential expression of genes associated with tissue repair and inflammation. Delivering pro-healing extracellular matrix by intravascular infusion post injury may provide translational advantages for the healing of inflamed tissues 'from the inside out'.
Indexed as
Biocompatible MaterialsMyocardial InfarctionAnimalsExtracellular MatrixHydrogelsMyocardiumRatsSwineBiocompatible MaterialsHydrogels
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