Evidence map›Paper›PMID 36581666›Full record

ArticleScientific reports2022

Ancient DNA from Protohistoric Period Cambodia indicates that South Asians admixed with local populations as early as 1st-3rd centuries CE.

Piya Changmai, Ron Pinhasi, Michael Pietrusewsky, Miriam T Stark, Rona Michi Ikehara-Quebral, David Reich, Pavel Flegontov

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Piya ChangmaiDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic. piya.changmai@osu.cz.
Ron PinhasiDepartment of Evolutionary Anthropology, University of Vienna, Vienna, Austria.
Michael PietrusewskyDepartment of Anthropology, University of Hawai'i-Mānoa, Honolulu, HI, USA.
Miriam T StarkDepartment of Anthropology, University of Hawai'i-Mānoa, Honolulu, HI, USA.
Rona Michi Ikehara-QuebralDepartment of Anthropology, University of Hawai'i-Mānoa, Honolulu, HI, USA.
David ReichDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA, USA. reich@genetics.med.harvard.edu.
Pavel FlegontovDepartment of Biology and Ecology, Faculty of Science, University of Ostrava, Ostrava, Czech Republic. pavel.flegontov@osu.cz.
University of Hawaiʻi at Mānoa · USHarvard University · USUniversity of Ostrava · CZUniversity of Vienna · AT

Funding

Solving ascertainment bias in ancient DNA using Ultima Genomics sequencingR01HG012287 · NHGRI · HARVARD MEDICAL SCHOOL · PI REICH, DAVID E · 2021 to 2025
$2.7M
NHGRI NIH HHS R01 HG012287
6 · The paper itself

Abstract

Indian cultural influence is remarkable in present-day Mainland Southeast Asia (MSEA), and it may have stimulated early state formation in the region. Various present-day populations in MSEA harbor a low level of South Asian ancestry, but previous studies failed to detect such ancestry in any ancient individual from MSEA. In this study, we discovered a substantial level of South Asian admixture (ca. 40-50%) in a Protohistoric individual from the Vat Komnou cemetery at the Angkor Borei site in Cambodia. The location and direct radiocarbon dating result on the human bone (95% confidence interval is 78-234 calCE) indicate that this individual lived during the early period of Funan, one of the earliest states in MSEA, which shows that the South Asian gene flow to Cambodia started about a millennium earlier than indicated by previous published results of genetic dating relying on present-day populations. Plausible proxies for the South Asian ancestry source in this individual are present-day populations in Southern India, and the individual shares more genetic drift with present-day Cambodians than with most present-day East and Southeast Asian populations.

Indexed as

DNA, AncientGenetics, PopulationCambodiaHumansSouth Asian PeopleDNA, Ancient

Identifiers

PMID36581666
PMCPMC9800559
OpenAlexW4313242242

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.