Evidence map›Paper›PMID 36581575›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2022

Buyang Huanwu decoction promotes angiogenesis of rat brain microvascular endothelial cells after oxygen-glucose deprivation reperfusion injury via activation of PI3K-AKT signaling pathway.

Xiaowei Hu, Lin Li, Yingying Gong, Yan Fang, Yan Yang, Jiadong Xu, Lisheng Chu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaowei Hu1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Lin Li1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yingying Gong2. The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yan Fang1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Yan Yang1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Jiadong Xu1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Lisheng Chu1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Zhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect and mechanism of Buyang Huanwu decoction (BYHWD) on angiogenesis of rat brain microvascular endothelial cells (RBMECs) after oxygen-glucose deprivation reperfusion (OGD/R) injury.

methodsRBMECs were pretreated with BYHWD containing serum 24 h before OGD/R injury was induced. Cells were randomly divided into blank control group, model control group, BYHWD group (provided BYHWD containing serum) and LY294002 group [treated with phosphoinositide 3-kinase (PI3K) inhibitor LY294002 for 1 h before provided BYHWD containing serum]. The cell viability, migration and tube formation abilities of RBMECs were detected by CCK-8, scratch wound healing, Transwell migration and tube formation assays, respectively. The protein expression levels of PI3K, p-PI3K, protein kinase B (AKT), p-AKT, hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) were determined by Western blotting.

resultsCompared with model control group, cell viability, migration and tube formation abilities of RBMECs were significantly improved in BYHWD group (all

conclusionBYHWD can promote angiogenesis of RBMECs after OGD/R injury, which may be related to the increased protein expression of HIF-1α and VEGF through activation of PI3K-AKT signaling pathway.

Indexed as

Phosphatidylinositol 3-KinaseReperfusion InjuryAnimalsBrainDrugs, Chinese HerbalEndothelial CellsGlucoseOxygenPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsSignal TransductionVascular Endothelial Growth Factor Abuyang huanwuDrugs, Chinese HerbalGlucoseOxygenPhosphatidylinositol 3-KinasePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktVascular Endothelial Growth Factor AAngiogenesisBrain microvascular endothelial cellsBuyang Huanwu decoctionHypoxia-inducible factor-1αOxygen- glucose deprivation reperfusionPI3K-AKT signaling pathwayVascular endothelial growth factor

Identifiers

PMID36581575
PMCPMC10264995
OpenAlexW4310365557

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.