ReviewSeminars in perinatology2023
Shaping infant development from the inside out: Bioactive factors in human milk.
Review in Seminars in perinatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Trial
- Association between breastfeeding and neurodevelopmental outcomes after late preterm birth.Pregnancy (Hoboken, N.J.) · 2026Article
- Maternal supplementation with rumen-protected arginine reshapes the ileal microbiome and enhances neonatal lamb growth.Animal microbiome · 2026Article
- Human milk microbiota: origins, determinants, and roles in maternal-infant microbial transmission and infant microbiome assembly.Frontiers in microbiology · 2026Review
- Characterization of Extracellular Vesicles From Fresh vs. Frozen Human Milk Including the Vesicular microRNA Cargo.Journal of extracellular biology · 2025Article
- Exosomes in Breast Milk: Their Impact on the Intestinal Microbiota of the Newborn and Therapeutic Perspectives for High-Risk Neonates.International journal of molecular sciences · 2025Review
- Microscopic messengers: Extracellular vesicles shaping gastrointestinal health and disease.Physiological reports · 2025Review
- Gut-X axis.iMeta · 2025Review
- Formula protein versus human milk protein and the effects on growth in preterm born infants.Current opinion in clinical nutrition and metabolic care · 2025Review
- Proteome characterization of extracellular vesicles from human milk: Uncovering the surfaceome by a lipid-based protein immobilization technology.Journal of extracellular biology · 2024Article
- From Womb to World: Exploring the Immunological Connections between Mother and Child.ImmunoHorizons · 2024Review
- Neonatal enteroids absorb extracellular vesicles from human milk-fed infant digestive fluid.Journal of extracellular vesicles · 2024Article
- Review
- Building better barriers: how nutrition and undernutrition impact pediatric intestinal health.Frontiers in immunology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Human breast milk is the optimal nutrition for all infants and is comprised of many bioactive and immunomodulatory components. The components in human milk, such as probiotics, human milk oligosaccharides (HMOs), extracellular vesicles, peptides, immunoglobulins, growth factors, cytokines, and vitamins, play a critical role in guiding neonatal development beyond somatic growth. In this review, we will describe the bioactive factors in human milk and discuss how these factors shape neonatal immunity, the intestinal microbiome, intestinal development, and more from the inside out.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.