ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Inflammation-Controlled Anti-Inflammatory Hydrogels.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Bridging epigenetics and pharmacology through systematic reviews tailored to WBS methodology: the triangle decision-making model as a pioneering translational biological drug delivery system.Frontiers in medicine · 2025Pooled it
- Trial
- Bioinspired microcapsule reactor with engineered probiotics for IBD therapy.Nature communications · 2026Article
- ROS-scavenging lipoic acid-modified chitosan hydrogels with rapid photocrosslinked ability accelerates peripheral nerve regeneration.Regenerative biomaterials · 2026Article
- Reprogramming the gastrointestinal microenvironment with intelligent biomaterials and digital medicine: a perspective on precision intervention for digestive diseases.Frontiers in bioengineering and biotechnology · 2026Article
- Hybrid Hydrogels in Pain Management Application: A Comprehensive Review.Clinical pharmacology : advances and applications · 2026Review
- Smart Hydrogels in Wearable Electronics for Wound Treatments.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Integrated bioprinting of trachea-like structures based on tissue-specific bioink.Materials today. Bio · 2025Article
- Pollen Integrated Hydrogel Patches With Hierarchical Structures and Spatio-Temporal Actives Release for Wound Healing.Smart medicine · 2025Article
- ROS-Responsive Microneedle Patches Enable Peri-Lacrimal Gland Therapeutic Administration for Long-Acting Therapy of Sjögren's Syndrome-Related Dry Eye.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cutting-Edge Hydrogel Technologies in Tissue Engineering and Biosensing: An Updated Review.Materials (Basel, Switzerland) · 2024Review
- Sprayable anti-adhesive hydrogel for peritoneal macrophage scavenging in post-surgical applications.Nature communications · 2024Article
- Biomimetic Anticoagulated Porous Particles with Self-Reporting Structural Colors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Design Strategies and Application Potential of Multifunctional Hydrogels for Promoting Angiogenesis.International journal of nanomedicine · 2024Review
- Inflammation-Controlled Anti-Inflammatory Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
While autoregulative adaptation is a common feature of living tissues, only a few feedback-controlled adaptive biomaterials are available so far. This paper herein reports a new polymer hydrogel platform designed to release anti-inflammatory molecules in response to the inflammatory activation of human blood. In this system, anti-inflammatory peptide drugs, targeting either the complement cascade, a complement receptor, or cyclophilin A, are conjugated to the hydrogel by a peptide sequence that is cleaved by elastase released from activated granulocytes. As a proof of concept, the adaptive drug delivery from the gel triggered by activated granulocytes and the effect of the released drug on the respective inflammatory pathways are demonstrated. Adjusting the gel functionalization degree is shown to allow for tuning the drug release profiles to effective doses within a micromolar range. Feedback-controlled delivery of covalently conjugated drugs from a hydrogel matrix is concluded to provide valuable safety features suitable to equip medical devices with highly active anti-inflammatory agents without suppressing the general immunosurveillance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.