Evidence map›Paper›PMID 36581466›Full record

ArticleNeurology2023

Cognitive and Functional Trajectories in Older Adults With Prediagnostic Parkinson Disease.

Meredith A Bock, Eric Vittinghoff, Amber L Bahorik, Yue Leng, Howard Fink, Kristine Yaffe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meredith A BockFrom the Departments of Neurology (M.A.B., K.Y.), Epidemiology and Biostatistics (E.V., K.Y.), Psychiatry (A.L.B., Y.L., K.Y.), and Weill Institute for Neuroscience (M.A.B., A.L.B., Y.L., K.Y.), University of California, San Francisco; San Francisco Veteran's Affairs Health Care System (M.A.B., K.Y.), California; and Geriatric Research Education and Clinical Center (H.F.), Minneapolis Veteran's Affairs Health Care System, Minesota. meredith.bock@ucsf.edu.ORCID 0000-0002-8704-916X
Eric VittinghoffFrom the Departments of Neurology (M.A.B., K.Y.), Epidemiology and Biostatistics (E.V., K.Y.), Psychiatry (A.L.B., Y.L., K.Y.), and Weill Institute for Neuroscience (M.A.B., A.L.B., Y.L., K.Y.), University of California, San Francisco; San Francisco Veteran's Affairs Health Care System (M.A.B., K.Y.), California; and Geriatric Research Education and Clinical Center (H.F.), Minneapolis Veteran's Affairs Health Care System, Minesota.
Amber L BahorikFrom the Departments of Neurology (M.A.B., K.Y.), Epidemiology and Biostatistics (E.V., K.Y.), Psychiatry (A.L.B., Y.L., K.Y.), and Weill Institute for Neuroscience (M.A.B., A.L.B., Y.L., K.Y.), University of California, San Francisco; San Francisco Veteran's Affairs Health Care System (M.A.B., K.Y.), California; and Geriatric Research Education and Clinical Center (H.F.), Minneapolis Veteran's Affairs Health Care System, Minesota.
Yue LengFrom the Departments of Neurology (M.A.B., K.Y.), Epidemiology and Biostatistics (E.V., K.Y.), Psychiatry (A.L.B., Y.L., K.Y.), and Weill Institute for Neuroscience (M.A.B., A.L.B., Y.L., K.Y.), University of California, San Francisco; San Francisco Veteran's Affairs Health Care System (M.A.B., K.Y.), California; and Geriatric Research Education and Clinical Center (H.F.), Minneapolis Veteran's Affairs Health Care System, Minesota.
Howard FinkFrom the Departments of Neurology (M.A.B., K.Y.), Epidemiology and Biostatistics (E.V., K.Y.), Psychiatry (A.L.B., Y.L., K.Y.), and Weill Institute for Neuroscience (M.A.B., A.L.B., Y.L., K.Y.), University of California, San Francisco; San Francisco Veteran's Affairs Health Care System (M.A.B., K.Y.), California; and Geriatric Research Education and Clinical Center (H.F.), Minneapolis Veteran's Affairs Health Care System, Minesota.
Kristine YaffeFrom the Departments of Neurology (M.A.B., K.Y.), Epidemiology and Biostatistics (E.V., K.Y.), Psychiatry (A.L.B., Y.L., K.Y.), and Weill Institute for Neuroscience (M.A.B., A.L.B., Y.L., K.Y.), University of California, San Francisco; San Francisco Veteran's Affairs Health Care System (M.A.B., K.Y.), California; and Geriatric Research Education and Clinical Center (H.F.), Minneapolis Veteran's Affairs Health Care System, Minesota.

Funding

Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
Long term fracture risk and change in peripheral bone in the oldest old men: The MrOS studyR01AG066671 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI BOUXSEIN, MARY L, CAWTHON, PEGGY MANNEN · 2020 to 2024
$13.3M
Outcomes of Sleep Disorders in Older MenR01HL071194 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI STONE, KATIE L · 2003 to 2013
$12.2M
Osteoporotic Fractures in Men (MrOS) - San Francisco Coordinating CenterU01AR066160 · NIAMS · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON · 2013 to 2017
$9.3M
Changes in Sleep and Cognition in Older WomenR01AG026720 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STONE, KATIE L, YAFFE, KRISTINE · 2006 to 2016
$7.5M
Study of Osteoporotic FracturesR01AG005394 · NIA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ENSRUD, KRISTINE · 1986 to 2015
$6.1M
Osteoporotic Fractures in Men (MrOS) - MinneapolisU01AG042145 · NIA · UNIVERSITY OF MINNESOTA · PI ENSRUD, KRISTINE · 2013 to 2019
$5.3M
Osteporotic Fractures in Men (MrOS)- Admin CenterU01AG027810 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2017
$5.1M
Population Based Research for Alzheimer's Innovation (POP BRAIN)R35AG071916 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YAFFE, KRISTINE · 2021 to 2024
$3.8M
Osteoporotic Fractures in Men (MrOS) - PortlandU01AG042124 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2013 to 2019
$3.0M
Osteoporatic Fractures in Men (MrOS)U01AG042168 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KADO, DEBORAH · 2013 to 2017
$3.0M
NCATS NIH HHS UL1 TR000128NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070839NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NIAMS NIH HHS U01 AR066160NIA NIH HHS R00 AG056598NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG026720NIA NIH HHS R01 AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG066671NIA NIH HHS R35 AG071916NIA NIH HHS U01 AG027810NIA NIH HHS U01 AG042124NIA NIH HHS U01 AG042139NIA NIH HHS U01 AG042140NIA NIH HHS U01 AG042143NIA NIH HHS U01 AG042145NIA NIH HHS U01 AG042168
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThere is increasing interest in characterizing the earliest phases of Parkinson disease (PD). However, few studies have investigated prediagnostic trajectories of cognition and function. Our objective was to describe prediagnostic cognitive and functional trajectories in PD in older women and men.

methodsWe studied 9,595 women and 5,795 men from 2 prospective cohort studies of community-dwelling elders followed up to 20 years. In individuals without prevalent PD, we estimated the associations of incident PD diagnosis with rates of change in cognition and function before and after diagnosis compared with healthy older adults using multivariate mixed-effects models.

resultsOver follow-up, 297 individuals developed incident PD. Interactions between the terms in our model and sex were statistically significant for the 3 outcomes ( DISCUSSION: Individuals with incident PD exhibit cognitive and functional decline during the prediagnostic phase that exceeds rates associated with normal aging. Better understanding heterogeneity in prodromal PD is essential to enable earlier diagnosis and identify impactful nonmotor symptoms in all subgroups.

Indexed as

Cognitive DysfunctionParkinson DiseaseAgedAgingCognitionExecutive FunctionFemaleHumansMaleProspective Studies

Identifiers

PMID36581466
PMCPMC10065215

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.