Evidence map›Paper›PMID 36581424›Full record

ArticleBMJ open2022

Hospitalised COVID-19 outcomes are predicted by hypoxaemia and pneumonia phenotype irrespective of the timing of their emergence.

Brittany Salter, Bianca DeBenedictis, Laura Spatafora, Jessica Kapralik, Candice Luo, Steven Qiu, Laura Dawson, Mats Junek, Tyler Pitre, Aaron Jones and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Brittany SalterDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada brittany.salter@medportal.ca.ORCID 0000-0002-4253-2924
Bianca DeBenedictisDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Laura SpataforaDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Jessica KapralikDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Candice LuoDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Steven QiuDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Laura DawsonDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Mats JunekDepartment of Rheumatology, McMaster University, Hamilton, Ontario, Canada.
Tyler PitreDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-3015-0723
Aaron JonesDepartment of Health Research Methods, Evidence, and Impact, McMaster University Faculty of Health Sciences, Hamilton, Ontario, Canada.ORCID 0000-0002-6282-3614
Marla BeauchampSchool of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0003-2843-388X
Rebecca KruisselbrinkDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
MyLinh DuongRespirology, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-9197-2547
Andrew P CostaMcMaster University, Hamilton, Ontario, Canada.ORCID 0000-0001-9212-5641
Jennifer Ly TsangDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-1809-0505
Terence HoDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID 0000-0002-0412-6538
McMaster University · CAImpact · CANiagara Health System · CA

Funding

CIHR 172754
6 · The paper itself

Abstract

Despite the known clinical importance of hypoxemia and pneumonia, there is a paucity of evidence for these variables with respect to risk of mortality and short-term outcomes among those hospitalised with COVID-19.

objectiveDescribe the prevalence and clinical course of patients hospitalised with COVID-19 based on oxygenation and pneumonia status at presentation and determine the incidence of emergent hypoxaemia or radiographic pneumonia during admission.

methodsA retrospective study was conducted using a Canadian regional registry. Patients were stratified according to hypoxaemia/pneumonia phenotype and prevalence. Clinical parameters were compared between phenotypes using χ

resultsAt emergency department (ED) admission, the prevalence of pneumonia and hypoxaemia was 43% and 50%, respectively, and when stratified to phenotypes: 28.2% hypoxaemia

conclusionMortality in COVID-19 infection is predicted by hypoxaemia with or without pneumonia and was greatest in patients who initially presented with hypoxaemia. The emergence of hypoxaemia was predicted by radiographic pneumonia. Patients with early and emergent hypoxaemia had similar mortality but were less likely to be admitted to ICU. There may be delayed identification of hypoxaemia, which prevents timely escalation of care.

Indexed as

COVID-19PneumoniaCanadaHumansHypoxiaIntensive Care UnitsRetrospective Studiesadult intensive & critical careadult thoracic medicineCOVID-19public healthrespiratory infectionsthoracic medicine

Identifiers

PMID36581424
PMCPMC9805826
OpenAlexW4313271249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.