SynthesisBMJ global health2022
Incidence and outcomes of intrapartum-related neonatal encephalopathy in low-income and middle-income countries: a systematic review and meta-analysis.
Synthesis in BMJ global health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- MRI scoring systems in neonatal encephalopathy and neurodevelopmental outcomes: a systematic review.Journal of perinatology : official journal of the California Perinatal Association · 2026Pooled it
- Predictors of outcome following neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Acupuncture for hypoxic ischemic encephalopathy in neonates.The Cochrane database of systematic reviews · 2024Pooled it
- Pediatric spasticity in Brazil: insights from a neurosurgical referral center.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Predictors of adverse outcome in infants with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: a real-world cohort study.BMC pediatrics · 2026Article
- Development and validation of a clinical prediction model for neonatal seizures among neonates admitted to public health hospitals in Northwest Ethiopia: retrospective follow-up study.Italian journal of pediatrics · 2026Article
- N-Acetylcysteine Reduces Tissue Injury Induced by Oxygen-Glucose Deprivation in an Organotypic Culture of Mouse Cerebral Cortex Slices.Children (Basel, Switzerland) · 2026Article
- Editorial: Evaluating efficacy and outcomes in neonatal HIE treatment: A global perspective.Frontiers in pediatrics · 2026Article
- Neonatal encephalopathy and hypoxic-ischemic encephalopathy: the state of the art.Pediatric research · 2025Review
- A description of feeding and swallowing in neonates with hypoxic ischemic encephalopathy.The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings · 2025Article
- Neonatal encephalopathy in India: spatiotemporal variations in declining mortality.Pediatric research · 2025Article
- Use and implications of the Apgar score in evaluating resuscitation of newborns with birth asphyxia in a lower-middle-income country.Journal of global health · 2025Article
- Impact of teleneonatology on time to goal temperature in outborn neonates with hypoxic-ischemic encephalopathy requiring therapeutic hypothermia.Journal of perinatology : official journal of the California Perinatal Association · 2025Observational
- Genetic Variants Associated with Suspected Neonatal Hypoxic Ischaemic Encephalopathy: A Study in a South African Context.International journal of molecular sciences · 2025Article
- Socio-medical factors associated with neurodevelopmental disorders on the Kenyan coast.PLOS global public health · 2025Article
- Therapeutic hypothermia for neonatal hypoxic ischaemic encephalopathy in Sub-Saharan Africa: A scoping review.PloS one · 2025Article
- Minimal impact of feed intolerance during therapeutic hypothermia for hypoxic ischaemic encephalopathy in a South African cohort with a standardised feeding regimen.Frontiers in pediatrics · 2025Article
- Persistent inequities in neonatal encephalopathy: a 30-year global burden analysis (1990-2021).Frontiers in pediatrics · 2025Article
- Article
- Understanding the role of the placenta in neonatal encephalopathy and outcome.Pediatric research · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
aimTo examine the incidence of intrapartum-related neonatal encephalopathy, and neonatal mortality and neurodevelopmental outcomes associated with it in low-income and middle-income countries.
methodsReports were included when neonatal encephalopathy diagnosed clinically within 24 hours of birth in term or near-term infants born after intrapartum hypoxia-ischaemia defined as any of the following: (1) pH≤7.1 or base excess ≤-12 or lactate ≥6, (2) Apgar score ≤5 at 5 or 10 min, (3) continuing resuscitation at 5 or 10 min or (4) no cry from baby at 5 or 10 min. Peer-reviewed articles were searched from Ovid MEDLINE, Cochrane, Web of Science and WHO Global Index Medicus with date limits 1 November 2009 to 17 November 2021. Risk of bias was assessed using modified Newcastle Ottawa Scale. Inverse variance of heterogenicity was used for meta-analyses.
resultsThere were 53 reports from 51 studies presenting data on 4181 children with intrapartum-related neonatal encephalopathy included in the review. Only five studies had data on incidence, which ranged from 1.5 to 20.3 per 1000 live births. Neonatal mortality was examined in 45 studies and in total 636 of the 3307 (19.2%) infants died. Combined outcome of death or moderate to severe neurodevelopmental disability was reported in 19 studies and occurred in 712 out of 1595 children (44.6%) with follow-up 1 to 3.5 years.
conclusionThough there has been progress in some regions, incidence, case mortality and morbidity in intrapartum-related neonatal encephalopathy has been static in the last 10 years. PROSPERO REGISTRATION NUMBER: CRD42020177928.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.