Evidence map›Paper›PMID 36581322›Full record

ArticleJournal of medicinal chemistry2023

Systematic Design of Adenosine Analogs as Inhibitors of a

Jujun Zhou, John R Horton, Martina Menna, Francesco Fiorentino, Ren Ren, Dan Yu, Taraneh Hajian, Masoud Vedadi, Giulia Mazzoccanti, Alessia Ciogli and 7 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Conditioning chemotherapy exposure is associated with epigenetic modifications inmedRxiv : the preprint server for health sciences · 2026
    Article
  3. Inhibition ofACS omega · 2025
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  4. Inhibition ofbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 4 countries.

Jujun ZhouDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
John R HortonDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Martina MennaDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Francesco FiorentinoDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0003-3550-1860
Ren RenDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Dan YuDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Taraneh HajianStructural Genomics Consortium, University of Toronto, Toronto, ON M5S 1A8, Canada.
Masoud VedadiStructural Genomics Consortium, University of Toronto, Toronto, ON M5S 1A8, Canada.ORCID 0000-0002-0574-0169
Giulia MazzoccantiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Alessia CiogliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-7538-2424
Elmar WeinholdInstitute of Organic Chemistry, RWTH Aachen University, D-52056 Aachen, Germany.
Michael HübenInstitute of Organic Chemistry, RWTH Aachen University, D-52056 Aachen, Germany.
Robert M BlumenthalDepartment of Medical Microbiology and Immunology, and Program in Bioinformatics, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio 43614, United States.
Xing ZhangDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0001-9176-2382
Dante RotiliDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.ORCID 0000-0002-8428-8763
Xiaodong ChengDepartment of Epigenetics and Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, United States.ORCID 0000-0002-6967-6362
The University of Texas MD Anderson Cancer Center · USSapienza University of Rome · ITRWTH Aachen University · DEUniversity of Toronto · CAIstituto Pasteur · ITUniversity of Toledo · US

Funding

Epigenetic regulations of DNA and histone methylation and deMethylation: Structures and MechanismsR35GM134744 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Xiaodong Cheng · 2020 to 2026
$4.5M
Phase II SER-CAT Optimization: Acquisition of a next generation area detectorS10RR028976 · NCRR · UNIVERSITY OF GEORGIA · PI WANG, BI-CHENG · 2010 to 2010
$1.5M
Acquisition of a High Precision Micro Diffractometer to Support NIH funded Research at SER-CATS10OD027000 · OD · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2019 to 2019
$600k
Acquition of a microdiffractometer for SER-CATS10RR025528 · NCRR · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2009 to 2009
$414k
NCRR NIH HHS S10 RR025528NCRR NIH HHS S10 RR028976NIGMS NIH HHS R35 GM134744NIH HHS S10 OD027000
6 · The paper itself

Abstract

Antivirulence agents targeting endospore-transmitted

Indexed as

Clostridioides difficileMethyltransferasesAdenineAdenosineAnimalsDNAHumansMammalsProtein-Arginine N-MethyltransferasesS-AdenosylmethionineAdenineAdenosineDNAMethyltransferasesProtein-Arginine N-MethyltransferasesS-Adenosylmethionine

Identifiers

PMID36581322
PMCPMC9841527
OpenAlexW4313288547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.