Evidence map›Paper›PMID 36581302›Full record

ArticleBioorganic & medicinal chemistry letters2023

Role of symmetry in 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as inhibitors of translation initiation.

Hongwei Yang, Ting Chen, Séverine Denoyelle, Limo Chen, Jing Fan, Yingzhen Zhang, José A Halperin, Michael Chorev, Bertal H Aktas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hongwei YangBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA. Electronic address: hyang@mail.njust.edu.cn.
Ting ChenBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA.
Séverine DenoyelleBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA.
Limo ChenBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA.
Jing FanBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA.
Yingzhen ZhangBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA.
José A HalperinBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA; Harvard Medical School, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA.
Michael ChorevBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA; Harvard Medical School, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA. Electronic address: mchorev.g@gmail.com.
Bertal H AktasBrigham and Women's Hospital, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA; Harvard Medical School, Division of Hematology, 4 Balckfan Circle. HIM 7, Boston, MA 02115, USA. Electronic address: Huseyin_aktas@hms.harvard.edu.
Brigham and Women's Hospital · USHarvard University · US

Funding

Targeting Endoplasmic Reticulum Stress Response for Cancer TherapyR01CA152312 · NCI · HARVARD MEDICAL SCHOOL · PI AKTAS, BERTAL H. · 2011 to 2015
$1.8M
NCI NIH HHS R01 CA152312
6 · The paper itself

Abstract

The ternary complex (eIF2·GTP·Met-tRNA

Indexed as

Biphenyl CompoundsEukaryotic Initiation Factor-2IndolesOxindolesPhosphorylationProtein Biosynthesis2-oxindole3,3-diphenyl-1,3-dihydroindol-2-onebiphenylBiphenyl CompoundsEukaryotic Initiation Factor-2IndolesOxindoles

Identifiers

PMID36581302
PMCPMC9922553
OpenAlexW4312222076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.