ArticleJournal of the American Academy of Dermatology2023
Clinical, histopathologic, immunohistochemical, and electron microscopic findings in cutaneous monkeypox: A multicenter retrospective case series in Spain.
Article in Journal of the American Academy of Dermatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Seminal fluid enhances monkeypox virus infection via amyloidogenic fibrils.Emerging microbes & infections · 2026Article
- A comprehensive overview of monkeypox virus disease.Tropical medicine and health · 2026Review
- Recent advances in Mpox across innate immunity, evasion, and clinical outcomes.Communications biology · 2026Review
- Photo Quiz: Persistent papules in an immunocompromised child.Journal of clinical microbiology · 2026Article
- The emergence of Clade IIb and Ib mpox viruses: a state-of-the-art review.Annals of medicine and surgery (2012) · 2026Review
- From skin lesions to multi-organ involvement: Organ tropism and pathogenesis of mpox virus.iScience · 2025Review
- Monkeypox Virus Subverts the Inflammatory Response of Macrophages at the Maternal-Fetal Interface.Journal of medical virology · 2025Article
- Detecting Monkeypox Virus by Immunohistochemistry.Journal of cutaneous pathology · 2025Article
- Navigating monkeypox: identifying risks and implementing solutions.Open veterinary journal · 2024Review
- Response to Rodríguez-Cuadrado et al's "Clinical, histopathologic, immunohistochemical, and electron microscopic findings in cutaneous monkeypox: A multicenter retrospective case series in Spain".JAAD case reports · 2024Article
- Cytopathic changes in mpox and herpesvirus infections: Role of histopathology and Tzanck smear.JAAD case reports · 2024Article
- Mpox Virus and its ocular surface manifestations.The ocular surface · 2024Review
- Review
- The Re-Emergence of Mpox: Old Illness, Modern Challenges.Biomedicines · 2024Review
- Necrotic ulcers in a HIV-positive man.JAAD case reports · 2024Article
- Histopathologic and transmission electron microscopic findings in monkeypox cutaneous lesions.Le infezioni in medicina · 2024Article
- [Monkeypox: case series].Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2023Article
- Detection of monkeypox virus using helicase dependent amplification and recombinase polymerase amplification combined with lateral flow test.Virology journal · 2023Article
- Review
- Lives of Skin Lesions in Monkeypox: Histomorphological, Immunohistochemical, and Clinical Correlations in a Small Case Series.Viruses · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe worldwide outbreak of monkeypox has evidenced the usefulness of the dermatologic manifestations for its diagnosis.
objectiveTo describe the histopathologic and immunohistochemical findings of monkeypox cutaneous lesions.
methodsThis is a retrospective histopathologic and immunohistochemical study of 20 patients with positive Monkeypox virus DNA polymerase chain reaction and immunohistochemical positivity for Vaccinia virus in cutaneous lesions. Four cases were also examined by electron microscopy.
resultsThe most characteristic histopathologic findings consisted of full-thickness epidermal necrosis with hyperplasia and keratinocytic ballooning at the edges. In some cases, the outer root sheath of the hair follicle and the sebaceous gland epithelium were affected. Intraepithelial cytoplasmic inclusion bodies and scattered multinucleated keratinocytes were occasionally found. Immunohistochemically, strong positivity with anti-Vaccinia virus antibody was seen in the cytoplasm of ballooned keratinocytes. Electron microscopy study demonstrated numerous viral particles of monkeypox in affected keratinocytes. LIMITATIONS: Small sample size. Electron microscopic study was only performed in 4 cases.
conclusionEpidermal necrosis and keratinocytic ballooning are the most constant histopathologic findings. Immunohistochemical positivity for Vaccinia virus was mostly detected in the cytoplasm of the ballooned keratinocytes. These findings support the usefulness of histopathologic and immunohistochemical studies of cutaneous lesions for diagnosis of monkeypox.
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