ArticleArquivos de neuro-psiquiatria2022
Pulmonary function and medication effect in mild-stage subjects with Parkinson's disease.
Article in Arquivos de neuro-psiquiatria, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Pulmonary Function in Parkinson's Disease: A Comparative Study of Spirometry and Impulse Oscillometry.Biomedicines · 2026Article
- Exploring Pulmonary Dysfunction in Parkinson's Disease: The Role of Impulse Oscillometry-A Systematic Review.Journal of clinical medicine · 2025Review
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) causes a series of movement disorders, many of them starting in the early stage.
objectiveTo analyze the pulmonary function of mild-stage subjects with PD and to investigate the effects of levodopa on it.
methodsWe included 21 patients with idiopathic PD and 20 healthy control subjects. The participants were submitted to spirometry and impulse oscillometry assessments. The PD patients were evaluated during the "off" and "on" phases of their anti-PD medication, which was was converted to levodopa in an equivalent daily dose. A statistical analysis was performed with cross-sectional (PD patients "off" medication versus controls) and paired (PD patients "off" medication versus PD patients "on" medication) tests. The effect of levodopa was calculated with partial Eta-squared (η
resultsThe PD patients presented normal values in the impulse oscillometry. Regarding spirometry, the results indicated an incipient obstructive ventilatory disorder in the PD group - confirmed by patients' flow-volume curves. The PD patients received a daily dose of 354.7 ± 148.2 mg of levodopa. The paired analyses showed a small effect of anti-PD medication on pulmonary parameters (η
conclusionPatients with PD in the mild stage of the disease present pulmonary compliance and resistance compatible with normal parameters. The differences regarding the spirometric results indicate an incipient obstructive ventilatory disorder in patients with PD. Levodopa had small effect on pulmonary function in the mild stage of the disease.
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