Evidence map›Paper›PMID 36580536›Full record

ArticleOncotarget2022

Calcium signaling induced by 15-deoxy-prostamide-J2 promotes cell death by activating PERK, IP3R, and the mitochondrial permeability transition pore.

Daniel A Ladin, Margaret M Nelson, Estefani Cota, Catherine Colonna, Colin Burns, Jacques Robidoux, Kelsey H Fisher-Wellman, Rukiyah Van Dross-Anderson

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Apoptosis mechanisms induced by 15d-PMJFrontiers in pharmacology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Daniel A LadinMedical Doctor Program, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Margaret M NelsonEast Carolina Diabetes and Obesity Institute at East Carolina University, Greenville, NC 27834, USA.
Estefani CotaDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
Catherine ColonnaMedical Doctor Program, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.
Colin BurnsDepartment of Chemistry, East Carolina University, Greenville, NC 27858, USA.
Jacques RobidouxEast Carolina Diabetes and Obesity Institute at East Carolina University, Greenville, NC 27834, USA.
Kelsey H Fisher-WellmanEast Carolina Diabetes and Obesity Institute at East Carolina University, Greenville, NC 27834, USA.
Rukiyah Van Dross-AndersonDepartment of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.
East Carolina University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanoma is the deadliest form of skin cancer in the US. Although immunotherapeutic checkpoint inhibitors and small-molecule kinase inhibitors have dramatically increased the survival of patients with melanoma, new or optimized therapeutic approaches are still needed to improve outcomes. 15-deoxy-Δ

Indexed as

MelanomaMitochondrial Permeability Transition PoreApoptosisCalciumCalcium SignalingCell DeathHumansProstaglandin D2CalciumMitochondrial Permeability Transition PoreProstaglandin D2calciumcancerendoplasmic reticulum stressmitochondrial respirationprostamide

Identifiers

PMID36580536
PMCPMC9799328
OpenAlexW4313263611

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.