Evidence map›Paper›PMID 36580229›Full record

ArticleInfection2023

Brain abscess with Ureaplasma parvum in a patient with granulomatosis with polyangiitis.

Marie Madlener, Marianne Breuninger, Arne Meißner, Henning Stetefeld, Sergej Telentschak, Thorsten Wille, Thilo van Eimeren, Norma Jung

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Beyond the Urogenital Tract, the Role ofDiagnostics (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Prostatic Abscess due toCase reports in infectious diseases · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marie MadlenerDepartment of Neurology, Faculty of Medicine, University of Cologne, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany. marie.madlener@uk-koeln.de.
Marianne BreuningerDepartment I of Internal Medicine, Faculty of Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Arne MeißnerDepartment of Hospital Hygiene and Infection Control, Faculty of Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Henning StetefeldDepartment of Neurology, Faculty of Medicine, University of Cologne, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.
Sergej TelentschakCenter for Neurosurgery, Faculty of Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Thorsten WilleInstitute for Medical Microbiology, Immunology and Hygiene, Faculty of Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
Thilo van EimerenDepartment of Neurology, Faculty of Medicine, University of Cologne, University Hospital Cologne, Kerpener Straße 62, 50937, Cologne, Germany.
Norma JungDepartment I of Internal Medicine, Faculty of Medicine, University of Cologne, University Hospital Cologne, Cologne, Germany.
University Hospital Cologne · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUreaplasma species are associated with urogenital infections, infertility and adverse pregnancy outcomes as well as neonatal infections. Involvement of the central nervous system in adults is extremely rare. We report an unusual case of a brain abscess secondary to otitis media with Ureaplasma parvum in a patient with granulomatosis with polyangiitis (GPA).

methodsImaging and laboratory findings, treatment decisions, and outcome of this case are explicated.

resultsA young adult with GPA presented with progredient earache after ambulant diagnosis of otitis media. Despite different courses of broad-spectrum antibiotic therapy, she developed meningoencephalitis due to mastoiditis following temporal abscess formation. Mastoidectomy and neurosurgical abscess removal were performed. Standard cultures of cerebrospinal fluid, blood and intracranial abscess material, as well as polymerase chain reaction (PCR) for common bacterial and viral meningitis pathogens remained negative. Only eubacterial PCR of intracranial abscess material returned positive for Ureaplasma parvum. The patient finally improved under antibiotic therapy with moxifloxacin and doxycycline.

conclusionUreaplasma species are rare causative pathogens in immunocompromised patients. They should be considered in patients with humoral immunodeficiencies with culture-negative infections failing standard therapy. Eubacterial PCR should be performed in early states of infection in these patients for immediate diagnosis and initiation of appropriate treatment to prevent adverse outcomes.

Indexed as

Brain AbscessGranulomatosis with PolyangiitisOtitis MediaUreaplasma InfectionsAnti-Bacterial AgentsFemaleHumansInfant, NewbornPregnancyUreaplasmaYoung AdultAnti-Bacterial AgentsBrain abscessCase reportGranulomatosis with polyangiitisRituximabUreaplasma

Identifiers

PMID36580229
PMCPMC10205844
OpenAlexW4313280740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.