Evidence map›Paper›PMID 36580158›Full record

ArticleInflammopharmacology2023

Trihydroxyxanthones from the heartwood of Maclura cochinchinensis modulate M1/M2 macrophage polarisation and enhance surface TLR4.

Chutima Jansakun, Wanatsanan Chulrik, Janejira Hata, Tanyarath Utaipan, Wachirachai Pabuprapap, Nassareen Supaweera, Onchuma Mueangson, Apichart Suksamrarn, Warangkana Chunglok

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Chutima JansakunSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0002-7892-4436
Wanatsanan ChulrikHealth Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0003-2804-4921
Janejira HataDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.ORCID http://orcid.org/0000-0003-3358-8712
Tanyarath UtaipanDepartment of Science, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani, 94000, Thailand.ORCID http://orcid.org/0000-0001-5092-2669
Wachirachai PabuprapapDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.ORCID http://orcid.org/0000-0001-6445-7550
Nassareen SupaweeraHealth Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0001-8583-0262
Onchuma MueangsonSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0002-8773-6621
Apichart SuksamrarnDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.ORCID http://orcid.org/0000-0001-8919-3555
Warangkana ChunglokSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand. cwarang@wu.ac.th.ORCID http://orcid.org/0000-0002-8000-6052
Walailak University · THRamkhamhaeng University · THPrince of Songkla University · TH

Funding

Royal Golden Jubilee (RGJ) Ph.D. Programme RGJ PHD/0216/2561
6 · The paper itself

Abstract

The anti-inflammatory actions of phytochemicals have attracted much attention due to the current state of numerous inflammatory disorders. Thai traditional medicine uses Maclura cochinchinensis (Lour.) Corner to treat chronic fever and various inflammatory diseases, as well as to maintain normal lymphatic function. Five flavonoids and five xanthones were isolated from the heartwood of M. cochinchinensis and we investigated the anti-inflammatory properties of the isolated compounds. All isolated compounds possessed an anti-inflammatory effect by decreasing prostaglandin E

Indexed as

MacluraXanthonesAnimalsAnti-Inflammatory AgentsCytokinesInflammationLipopolysaccharidesMacrophagesMiceNF-kappa BNitric Oxide Synthase Type IIToll-Like Receptor 4Anti-Inflammatory AgentsCytokinesLipopolysaccharidesNF-kappa BNitric Oxide Synthase Type IITlr4 protein, mouseToll-Like Receptor 4XanthonesInflammationMaclura cochinchinensisMacrophage polarisationToll-like receptorTrihydroxyxanthone

Identifiers

PMID36580158
OpenAlexW4313240849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.