Evidence map›Paper›PMID 36580119›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2023

Reduction in anti-seizure medications use in pediatric patients with pharmacoresistant epilepsy submitted to surgical treatment.

Maiave Micaelle Figueiredo de Matos, Larissa Aparecida Batista, Ursula Thomé, Américo Ceiki Sakamoto, Marcelo Volpon Santos, Hélio Rubens Machado, Lauro Wichert-Ana, Ana Paula Andrade Hamad

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maiave Micaelle Figueiredo de MatosDepartment of Neurosciences and Behavioural Sciences, Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Larissa Aparecida BatistaCenter for Epilepsy Surgery (CIREP), Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto, São Paulo, CEP, Brazil.
Ursula ThoméCenter for Epilepsy Surgery (CIREP), Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto, São Paulo, CEP, Brazil.
Américo Ceiki SakamotoDepartment of Neurosciences and Behavioural Sciences, Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Marcelo Volpon SantosCenter for Epilepsy Surgery (CIREP), Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto, São Paulo, CEP, Brazil.
Hélio Rubens MachadoCenter for Epilepsy Surgery (CIREP), Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto, São Paulo, CEP, Brazil.
Lauro Wichert-AnaCenter for Epilepsy Surgery (CIREP), Preto Medical School, University of São Paulo, Bandeirantes Avenue, Ribeirão Preto, São Paulo, CEP, Brazil.
Ana Paula Andrade HamadDepartment of Neurosciences and Behavioural Sciences, Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. anahamad@fmrp.usp.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to analyze the potential for postoperative (PO) medication suspension and reduction, emphasizing passive withdrawal.

methodsRetrospective study of patients under 18 years old submitted to surgical treatment for pharmacoresistant epilepsy and classified as Engel I during the first year of PO follow-up. Therapeutic management was evaluated through discontinuation or reduction of medications, both in terms of the number of ASM prescribed and in daily maintenance dosages in mg/kg.

resultsASM withdrawal started in the first year PO and occurred in 1.2% of cases, with a significant yearly reduction in the number of ASM during follow-up (p < 0.001). A comparison of the most commonly used ASM in daily mg/kg between the preoperative period (preop) and PO showed a reduction of ASM maintenance dosages during PO. Even though recurrence of seizures was observed 5 years after surgery, 125 patients (85%) were still classified as Engel I, albeit a higher number of ASM per patient was observed. Most patients showed no changes in cognitive and adaptive behavior evaluation between preop and PO, even in those who were able to reduce ASM.

conclusionSignificant reduction observed both in the number and daily maintenance dosages of ASM following each year of PO may be an indirect measure of the effectiveness of epilepsy surgery.

Indexed as

AnticonvulsantsEpilepsyAdolescentChildHumansNeurosurgical ProceduresRetrospective StudiesTreatment OutcomeAnticonvulsantsAnti-seizure medication reductionAnti-seizure medication withdrawalEpilepsy surgeryPharmacoresistant epilepsy

Identifiers

PMID36580119
PMCPMC9798357

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.