Trial reportEuropean radiology2023
Predicting pathological complete response of neoadjuvant radiotherapy and targeted therapy for soft tissue sarcoma by whole-tumor texture analysis of multisequence MRI imaging.
Trial report in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Diagnostic accuracy of 18F-FDG and 68 Ga-FAPi PET/CT for patients with gastric carcinoma: a systematic review and meta-analysis.Annals of nuclear medicine · 2025Pooled it
- Delta radiomics: an updated systematic review.La Radiologia medica · 2024Pooled it
- Application of magnetic resonance imaging radiomics in endometrial cancer: a systematic review and meta-analysis.La Radiologia medica · 2024Pooled it
- Systematic review of machine learning-based radiomics approach for predicting microsatellite instability status in colorectal cancer.La Radiologia medica · 2023Pooled it
- Trial
- Reproducibility of radiomics quality score: an intra- and inter-rater reliability study.European radiology · 2024Trial
- Apparent diffusion coefficient metrics for treatment response assessment in soft tissue sarcoma: Reproducibility and prognostic value of whole-tumor and sub-regional analysis.Skeletal radiology · 2026Article
- MRI features outperform histologic grade for outcome prediction in translocation-driven enriched soft-tissue sarcoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Prediction of adverse neonatal outcomes in pregnancy-induced hypertension using IVIM-DWI-based microstructure, microcirculation, and multisequence MR texture features.Abdominal radiology (New York) · 2026Article
- Tumor habitat characteristics derived from intravoxel incoherent motion for early response assessment in soft tissue sarcoma undergoing neoadjuvant radiotherapy and targeted therapy: a phase II study.Translational cancer research · 2026Article
- Evaluating the predictive efficacy of multi-parameter MRI based radiomic models on clinical symptom progression in perforator artery cerebral infarction.BMC medical imaging · 2026Article
- Disc degeneration did not lead to an increased incidence of adjacent vertebral fractures in wedge-type OVCF patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Degenerative scoliosis may trigger higher incidence of adjacent vertebral fractures following percutaneous vertebroplasty: a clinical evidence-based biomechanical research.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Wider screw spread can reduce the risk of short-term femoral head necrosis by optimizing the fixation stability in femoral neck fracture patients with triangle cannulated screw fixation.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2025Article
- Changes in facet orientation may simultaneously affect the potential risk of annulus tears and zygapophyseal joint osteoarthritis: a clinical review and biomechanical simulation.La Radiologia medica · 2025Article
- MRI-derived radiomics model for predicting intratumoral tertiary lymphoid structures in soft tissue sarcoma.Insights into imaging · 2025Article
- MRI-based texture analysis for the evaluation of the response to neoadjuvant chemoimmunotherapy in locally advanced head and neck squamous cell carcinoma.BMC medical imaging · 2025Article
- An OLIF Cage Integrated with a Low-Profile Plate and Cross Screws Could Reduce the Risk of Postoperative Complications Biomechanically.Annals of biomedical engineering · 2025Article
- Diffusion-/perfusion-weighted imaging fusion to automatically identify stroke within 4.5 h.European radiology · 2024Article
- A multimodal neural network with gradient blending improves predictions of survival and metastasis in sarcoma.NPJ precision oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo construct effective prediction models for neoadjuvant radiotherapy (RT) and targeted therapy based on whole-tumor texture analysis of multisequence MRI for soft tissue sarcoma (STS) patients.
methodsThirty patients with STS of the extremities or trunk from a prospective phase II trial were enrolled for this analysis. All patients underwent pre- and post-neoadjuvant RT MRI examinations from which whole-tumor texture features were extracted, including T
resultsFive of 30 patients (16.7%) achieved pCR. The Delta_Model (AUC 0.92) had a better predictive ability than the Pre_Model (AUC 0.78) and Post_Model (AUC 0.76) and was better than AJCC staging (AUC 0.52) and RECIST 1.1 criteria (AUC 0.52). The Combined_Model (pre, post, and delta features) had the best predictive performance (AUC 0.95).
conclusionWhole-tumor texture analysis of multisequence MRI can well predict pCR status after neoadjuvant RT and targeted therapy in STS patients, with better performance than RECIST 1.1 and AJCC staging. KEY POINTS: • MRI multisequence texture analysis could predict the efficacy of neoadjuvant RT and targeted therapy for STS patients. • Texture features showed incremental value beyond routine clinical factors. • The Combined_Model with features at multiple time points showed the best performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.