Evidence map›Paper›PMID 36579955›Full record

ArticleMagnetic resonance in medicine2023

A numerical human brain phantom for dynamic glucose-enhanced (DGE) MRI: On the influence of head motion at 3T.

Patrick M Lehmann, Anina Seidemo, Mads Andersen, Xiang Xu, Xu Li, Nirbhay N Yadav, Ronnie Wirestam, Patrick Liebig, Frederik Testud, Pia Sundgren and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Dynamic glucose-enhanced MRI in brain tumors.Magma (New York, N.Y.) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Patrick M LehmannDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID 0000-0003-1197-2975
Anina SeidemoDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID 0000-0002-0919-9680
Mads AndersenPhilips Healthcare, Copenhagen, Denmark.ORCID 0000-0002-2702-1640
Xiang XuBioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-8293-3776
Xu LiRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4350-3375
Nirbhay N YadavRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-0802-9791
Ronnie WirestamDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID 0000-0003-2628-0760
Patrick LiebigSiemens Healthcare GmbH, Erlangen, Germany.ORCID 0000-0001-7342-3715
Frederik TestudSiemens Healthcare AB, Malmö, Sweden.ORCID 0000-0003-4438-6227
Pia SundgrenLund University Bioimaging Centre, Lund University, Lund, Sweden.ORCID 0000-0001-9237-1236
Peter C M van ZijlRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins, University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-9706-1066
Linda KnutssonDepartment of Medical Radiation Physics, Lund University, Lund, Sweden.ORCID 0000-0002-4263-113X
Lund University · SEKennedy Krieger Institute · USHealthcare in Sweden · SEJohns Hopkins University · USSiemens Healthineers (Germany) · DE

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Development and Translation of D-glucose as a Diagnostic Agent for MRI of CancerR01EB019934 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2015 to 2019
$5.7M
Development and Translation of D-glucose as an MRI Contrast Agent for Multiple SclerosisR00EB026312 · NIBIB · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI XU, XIANG · 2020 to 2022
$747k
NIBIB NIH HHS R00 EB026312NIBIB NIH HHS R01 EB019934NICHD NIH HHS P50 HD103538
6 · The paper itself

Abstract

purposeDynamic glucose-enhanced (DGE) MRI relates to a group of exchange-based MRI techniques where the uptake of glucose analogues is studied dynamically. However, motion artifacts can be mistaken for true DGE effects, while motion correction may alter true signal effects. The aim was to design a numerical human brain phantom to simulate a realistic DGE MRI protocol at 3T that can be used to assess the influence of head movement on the signal before and after retrospective motion correction.

methodsMPRAGE data from a tumor patient were used to simulate dynamic Z-spectra under the influence of motion. The DGE responses for different tissue types were simulated, creating a ground truth. Rigid head movement patterns were applied as well as physiological dilatation and pulsation of the lateral ventricles and head-motion-induced B

resultsMotion artifacts similar to those previously reported for in vivo DGE data could be reproduced. Head movement of 1 mm translation and 1.5 degrees rotation led to a pseudo-DGE effect on the order of 1% signal change. B

conclusionDGE MRI studies can be corrupted by motion artifacts. Designing post-processing methods using retrospective motion correction including B

Indexed as

GlucoseImage Processing, Computer-AssistedArtifactsBrainHumansMagnetic Resonance ImagingMotionRetrospective StudiesRotationGlucoseCESTD-glucosedynamic glucose enhancedglucoCESTmotion correctionsimulations

Identifiers

PMID36579955
PMCPMC9992166
OpenAlexW4313281264

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.