ArticleJournal of the Korean Association of Oral and Maxillofacial Surgeons2022
Does platelet-rich fibrin increase bone regeneration in mandibular third molar extraction sockets?
Article in Journal of the Korean Association of Oral and Maxillofacial Surgeons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Evaluation of the usefulness of platelet-rich fibrin (PRF) in mandibular third molar surgery with 3D facial swelling analysis: a split-mouth randomized clinical trial.Head & face medicine · 2025Trial
- Prevalence of Mandibular Third Molar Impaction, Associated Pathologies, and Correlation With Temporomandibular Joint Morphology in a Hospital-Based Spanish Cohort: A Panoramic Radiography Study.International journal of dentistry · 2026Article
- Covered Socket Residuum (CSR) in Former Third Molar Sockets Despite Platelet-Rich Fibrin: A Prospective Randomized Controlled Split-Mouth Clinical Study.Bioengineering (Basel, Switzerland) · 2025Article
- Effects of ascorbic acid augmented albumin platelet-rich fibrin on the wound healing activity of human gingival fibroblasts: anJournal of the Korean Association of Oral and Maxillofacial Surgeons · 2024Article
- Article
- A Combination of Beta-tricalcium Phosphate, Plasmogel, and Platelet-rich Plasma Improves Long-term Bone Tissue Restoration after Complicated Lower Third Molar Surgery: A Nonrandomized Controlled Trial.Contemporary clinical dentistryArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: This study determined the effect of platelet-rich fibrin (PRF) on extraction socket bone regeneration and assessed the patterns and determinants of bone regeneration after the surgical extraction of impacted mandibular third molars. Materials and Methods: This prospective study randomly allocated 90 patients into two treatment groups: A PRF group (intervention group) and a non-PRF group (control group). After surgical extractions, the PRF group had PRF placed in the extraction socket and the socket was sutured, while the socket was only sutured in the non-PRF group. At postoperative weeks 1, 4, 8, and 12, periapical radiographs were obtained and HLImage software was used to determine the region of newly formed bone (RNFB) and the pattern of bone formation. The determinants of bone regeneration were assessed. Statistical significance was set at Results: The percentage RNFB (RNFB%) was not significantly higher in the PRF group when compared with the non-PRF group at postoperative weeks 1, 4, 8, and 12 ( Conclusion: Placement of PRF in extraction sockets increased socket bone regeneration. However, this finding was not statistically significant. The patient's sex, type of impaction, and duration of surgery significantly influenced the percentage of bone formation.
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Registered trials
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