Evidence map›Paper›PMID 36579890›Full record

ArticleeLife2022

Protein composition of axonal dopamine release sites in the striatum.

Lauren Kershberg, Aditi Banerjee, Pascal S Kaeser

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Proteomic insights into the biology of dopaminergic neurons.Frontiers in molecular neuroscience · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Molecular definition of distinct active zone protein machineries for CabioRxiv : the preprint server for biology · 2023
    Article
  15. Synaptotagmin-1 is a CaCell reports · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lauren KershbergDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-5676-4160
Aditi BanerjeeDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0003-2016-0717
Pascal S KaeserDepartment of Neurobiology, Harvard Medical School, Boston, United States.ORCID 0000-0002-1558-1958
Harvard University · US

Funding

Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Molecular Dissection of Active Zone Functions in Neurotransmitter ReleaseR01NS083898 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2014 to 2026
$5.9M
Super-Resolution ImagingP30NS072030 · NINDS · HARVARD MEDICAL SCHOOL · PI SABATINI, BERNARDO L · 2011 to 2020
$5.8M
Architecture and Function of Striatal Dopamine Signaling MachineryR01NS103484 · NINDS · HARVARD MEDICAL SCHOOL · PI Pascal Simon Kaeser · 2017 to 2026
$4.7M
Mechanisms of Vesicle Docking and Priming for Striatal Dopamine ReleaseF31NS105159 · NINDS · HARVARD MEDICAL SCHOOL · PI KERSHBERG, LAUREN HAYLEY · 2018 to 2021
$96k
NICHD NIH HHS P50 HD105351NINDS NIH HHS F31 NS105159NINDS NIH HHS P30 NS072030NINDS NIH HHS R01 NS083898NINDS NIH HHS R01 NS103484
6 · The paper itself

Abstract

Dopamine is an important modulator of cognition and movement. We recently found that evoked dopamine secretion is fast and relies on active zone-like release sites. Here, we used in vivo biotin identification (iBioID) proximity proteomics in mouse striatum to assess which proteins are present at these sites. Using three release site baits, we identified proteins that are enriched over the general dopamine axonal protein content, and they fell into several categories, including active zone, Ca

Indexed as

DopamineProteomicsAnimalsAxonsCorpus StriatumMiceMice, KnockoutSynaptic TransmissionDopamineactive zonecell biologydopamineexocytosismouseneuroscienceRIMSsecretionstriatum

Identifiers

PMID36579890
PMCPMC9937654
OpenAlexW4313261594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.