ArticlePsychiatry and clinical neurosciences2023
Effects of Japanese policies and novel hypnotics on long-term prescriptions of hypnotics.
Article in Psychiatry and clinical neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Efficacy and safety of each class of sleep medication for major depressive disorder with insomnia symptoms: A systematic review and meta-analysis of double-blind randomized controlled trials.Psychiatry and clinical neurosciences · 2025Pooled it
- Primary care physician characteristics and potentially inappropriate medications in older adults.Health affairs scholar · 2026Article
- Psychotropic Drug Scheduling and Benzodiazepine Receptor Agonist Prescribing in Japan: An Interrupted Time Series Analysis.Therapeutic innovation & regulatory science · 2026Article
- Article
- Quantitative determination of suvorexant, lemborexant, and daridorexant in human plasma using a MonoTip C18 and gas chromatography-mass spectrometry.Forensic toxicology · 2026Article
- Novel hypnotics use and hip fracture risk in middle-aged and older adults: A large, population-based cohort study in Japan.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Psychosocial characteristics of the general population who habitually use hypnotics: Results from a national survey on drug use among the Japanese.PCN reports : psychiatry and clinical neurosciences · 2024Article
- Treatment strategies for insomnia in Japanese primary care physicians' practice: A Web-based questionnaire survey.BMC primary care · 2024Article
- The effect of education regarding treatment guidelines for schizophrenia and major depressive disorders on psychiatrists' hypnotic medication prescribing behavior: a multicenter study.BMC psychiatry · 2024Article
- Treatment Failure and Long-Term Prescription Risk for Guideline-Recommended Hypnotics in Japan.JAMA network open · 2024Observational
- Association between benzodiazepine anxiolytic polypharmacy and concomitant psychotropic medications in Japan: a retrospective cross-sectional study.Frontiers in psychiatry · 2024Article
- Association between polypharmacy and the long-term prescription of hypnotics in Japan: a retrospective cross-sectional study.Frontiers in psychiatry · 2024Article
- Effect of education regarding treatment guidelines for schizophrenia and depression on the treatment behavior of psychiatrists: A multicenter study.Psychiatry and clinical neurosciences · 2023Article
- Prescription patterns of psychotropics for adults treated with ADHD medications: Analysis of the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) of 2019.PCN reports : psychiatry and clinical neurosciences · 2023Article
- A Comparison between Perceptions of Psychiatric Outpatients and Psychiatrists Regarding Benzodiazepine Use and Decision Making for Its Discontinuation: A Cross-Sectional Survey in Japan.International journal of environmental research and public health · 2023Article
- Treatment strategy for insomnia disorder: Japanese expert consensus.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
aimThe current study aimed to examine the effect of Japanese policies for appropriate hypnotics use and novel hypnotics (e.g. melatonin receptor agonist and orexin receptor antagonist [ORA]) on long-term prescriptions of hypnotics.
methodsThis retrospective study was conducted using a large-scale health insurance claims database. Among subscribers prescribed hypnotics at least once between April 2005 and March 2021, those prescribed hypnotics for the first time after being included in the database in three periods (period 1: April 2012-March 2013; period 2: April 2016-March 2017; and period 3: April 2018-March 2019) were eligible. These were set considering the timing of the 2014 and 2018 medical fee revisions (2014 for polypharmacy of three or more hypnotics, 2018 for long-term prescription of benzodiazepine receptor agonists for >12 months). The duration of consecutive prescriptions of hypnotics over 12 months was evaluated. Factors associated with short-term prescriptions of hypnotics were also investigated.
resultsIn total, 186 535 participants were newly prescribed hypnotics. The mean duration of prescriptions was 2.9 months, and 9.3% of participants were prescribed hypnotics for 12 months. Prescription periods were not associated with short-term prescriptions of hypnotics. ORA use was associated with short-term prescriptions of hypnotics (adjusted hazard ratio, 1.077 [95% confidence interval, 1.035-1.120]; P < 0.001), but melatonin receptor agonist use was not.
conclusionJapanese policies had no statistically significant effect on long-term prescriptions of hypnotics. Although this study suggests initiating ORA for insomniacs as a candidate strategy to prevent long-term prescriptions of hypnotics, further research is necessary to draw conclusions.
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