ArticleSleep2023
Association between insomnia phenotypes and subclinical myocardial injury: the Multi-Ethnic Study of Atherosclerosis.
Article in Sleep, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Insomnia nosology: a systematic review and critical appraisal of historical diagnostic categories and current phenotypes.Journal of sleep research · 2023Pooled it
- Association Between Insomnia With or Without Comorbid Sleep Apnea and Endothelial Dysfunction in COPD.CHEST pulmonary · 2026Article
- Insomnia and Cardiovascular Disease: Untangling a Complex Relationship.Journal of sleep research · 2026Review
- Comorbid Insomnia and Sleep Apnea Mechanistic Convergence, Phenotypic Heterogeneity, and Clinical Implications.Current sleep medicine reports · 2026Article
- Insomnia With Objective Short Sleep Duration Is Associated With Incident Cardiovascular and Cerebrovascular Disease: Evidence from the UK Biobank Data.Journal of the American Heart Association · 2026Article
- Sex-specific omics scores of sex hormones and associations with metabolic and sleep disorders.medRxiv : the preprint server for health sciences · 2026Article
- Mechanisms Linking Insomnia and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Obstructive sleep apnea comorbid with insomnia symptoms and objective short sleep duration is associated with incident hypertension.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Insomnia Phenotypes, Cardiovascular Risk and Their Link to Brain Health.Circulation research · 2025Review
- EEG spectral analysis of nighttime sleep and daytime MSLTs and neurocognitive evaluations in subjects with co-morbid insomnia and OSA.Respiratory research · 2025Article
- Associations of Everyday Discrimination With Insomnia and Short Sleep Duration Among Older Women.Journal of the American Heart Association · 2024Article
- Insomnia with objective but not subjective short sleep duration is associated with incident cardiovascular and/or cerebrovascular disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Sleep Bruxism and Sleep Structure in Comorbid Insomnia and Obstructive Sleep Apnea (COMISA) Syndrome: A Polysomnographic Study.Journal of clinical medicine · 2024Article
- Exploring shared biomarkers and shared pathways in insomnia and atherosclerosis using integrated bioinformatics analysis.Frontiers in molecular neuroscience · 2024Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
STUDY
objectivesTo assess whether the association between insomnia and subclinical myocardial injury, as measured by cardiac troponin T (cTnT), differs across insomnia phenotypes.
methodsWe measured cTnT in 2188 participants in the Multi-Ethnic Study of Atherosclerosis study who had completed sleep questionnaires and undergone unattended polysomnography (PSG) and 7-day actigraphy. Insomnia symptoms were defined as reporting at least one of the following ≥5 nights/week over the past 4 weeks: trouble falling asleep, waking up several times a night, having trouble getting back to sleep after waking up too early, or taking sleeping pills to help falling asleep. Obstructive sleep apnea (OSA) was defined as an apnea-hypopnea index (AHI >15 events/h). Participants were classified into insomnia phenotypes, including comorbid insomnia and OSA (COMISA) and insomnia associated with actigraphy-estimated short sleep (<6 h) or sleep fragmentation.
resultsThe mean age was 68.8 (SD 9.2) years, 53.6% were male. In total, 47.8% met threshold levels for insomnia symptoms, and 43.1% had an AHI >15. In adjusted linear regression models COMISA (β 0.08 [standard error (SE) 0.03], p < .01) and insomnia with short sleep duration (β 0.07 [SE 0.03], p < .05) were each associated with higher cTnT compared to a reference group with no insomnia. Insomnia with fragmented sleep (β 0.03 [SE 0.02]) was not associated with higher cTnT (p > .05) in adjusted analyses. OSA was associated with higher cTnT (β 0.09 [SE 0.03], p < .01) in adjusted models.
conclusionsCOMISA and insomnia with short sleep duration, but not insomnia symptoms alone or fragmented sleep, were associated with increased circulating cTnT in older adults.
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