Evidence map›Paper›PMID 36579516›Full record

ArticleJournal of personalized medicine2022

Speckle Contrast as Retinal Tissue Integrity Biomarker in Patients with Type 1 Diabetes Mellitus with No Retinopathy.

Elvira Orduna-Hospital, Maria Arcas-Carbonell, Ana Sanchez-Cano, Isabel Pinilla, Alejandra Consejo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elvira Orduna-HospitalDepartment of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain.ORCID 0000-0003-2710-1875
Maria Arcas-CarbonellDepartment of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain.
Ana Sanchez-CanoDepartment of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain.ORCID 0000-0002-5621-1937
Isabel PinillaAragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain.ORCID 0000-0003-0349-9997
Alejandra ConsejoDepartment of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain.ORCID 0000-0001-5186-1837
Universidad de Zaragoza · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study the retinal and choroidal layers in type 1 diabetes mellitus (DM1) without diabetic retinopathy (DR), using speckle contrast of optical coherence tomography (OCT) images as a tissue biomarker in comparison with healthy subjects.

methodsOCT Spectralis images of 148 eyes, 84 from DM1 patients without DR signs, and 64 belonging to the control group, were collected. The speckle contrast and thickness of the inner retinal layer (IRL), the outer retinal layer (ORL), and the choroidal layer in the nasal parafoveal area (N3), were prospectively analyzed.

resultsA statistically significant difference (

conclusionsStatistically significant differences were found in speckle contrast and thickness between the control and the DM1 group, suggesting an IRL alteration of DM1 patients, supporting the retinal neurodegeneration before DR signs are observed.

Indexed as

choroidinner retinal layeroptical coherence tomographyretinaspeckle contrasttype 1 diabetes mellitus

Identifiers

PMID36579516
PMCPMC9693211
OpenAlexW4307988520

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.