ArticleThe EMBO journal2023
Sensor NLR immune proteins activate oligomerization of their NRC helpers in response to plant pathogens.
Article in The EMBO journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- A built-in brake for plant immunity: Resistance (R) protein-mediated immunity is fine-tuned byScience advances · 2026Article
- Diverse haplotypes at a complex Solanum americanum locus confer resistance to Phytophthora infestans and P. capsici.The Plant cell · 2026Article
- Cross-species transfer of sensor and helper NLR confers resistance to black rot in Brassica oleracea.Molecular horticulture · 2026Article
- The C-terminal tail of Cf resistance proteins determines the intensity of the effector-triggered hypersensitive response-related cell death.Plant physiology · 2026Article
- Contrasting evolutionary patterns of helper and sensor NRC NLRs in lettuce reflect functional divergence following subfunctionalization.PLoS genetics · 2026Article
- A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity.Science advances · 2026Article
- A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome.Science advances · 2026Article
- Article
- Plant NLRs are getting into higher-order architectures.The Plant journal : for cell and molecular biology · 2026Review
- Subcellular calcium dynamics and organelle perturbations in resistosome-mediated cell death.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Unraveling plant immunity: from pathogen perception to resistance engineering.Science China. Life sciences · 2026Review
- Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The diverse roles of host membranes in plant-microbe interactions.PLoS pathogens · 2026Article
- Blue Native-PAGE Assay of NLR Protein Complexes Combined with Genetic Complementation in Nicotiana benthamiana.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Quantification of NLR-Induced Cell Death Using Rice Protoplasts.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Can AI modeling of protein structures distinguish between sensor and helper NLR immune receptors?The New phytologist · 2025Article
- The autoactivity of tomato helper NLR immune proteins of the NRC clade is unaltered in Nicotiana benthamiana prf mutants.Plant physiology · 2025Article
- Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses.The Plant cell · 2025Article
- Coordinated actions of NLR-assembled and glutamate receptor-like calcium channels in plant effector-triggered immunity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome-Wide Identification and Expression Analysis of the GH19 Chitinase Gene Family in Sea Island Cotton.Current issues in molecular biology · 2025Article
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Authors and funding
13 authors.
Funding
Abstract
Nucleotide-binding domain leucine-rich repeat (NLR) immune receptors are important components of plant and metazoan innate immunity that can function as individual units or as pairs or networks. Upon activation, NLRs form multiprotein complexes termed resistosomes or inflammasomes. Although metazoan paired NLRs, such as NAIP/NLRC4, form hetero-complexes upon activation, the molecular mechanisms underpinning activation of plant paired NLRs, especially whether they associate in resistosome hetero-complexes, is unknown. In asterid plant species, the NLR required for cell death (NRC) immune receptor network is composed of multiple resistance protein sensors and downstream helpers that confer immunity against diverse plant pathogens. Here, we show that pathogen effector-activation of the NLR proteins Rx (confers virus resistance), and Bs2 (confers bacterial resistance) leads to oligomerization of their helper NLR, NRC2. Activated Rx does not oligomerize or enter into a stable complex with the NRC2 oligomer and remains cytoplasmic. In contrast, activated NRC2 oligomers accumulate in membrane-associated puncta. We propose an activation-and-release model for NLRs in the NRC immune receptor network. This points to a distinct activation model compared with mammalian paired NLRs.
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