Evidence map›Paper›PMID 36579497›Full record

ReviewJournal of personalized medicine2022

Association between Early Phase Serum Albumin Levels and Outcomes of Post-Cardiac Arrest Patients: A Systematic Review and Meta-Analysis.

Heekyung Lee, Juncheol Lee, Hyungoo Shin, Tae-Ho Lim, Bo-Hyoung Jang, Youngsuk Cho, Wonhee Kim, Jae-Guk Kim, Kyu-Sun Choi, Min-Kyun Na and 2 more

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Heekyung LeeDepartment of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, Korea.ORCID 0000-0001-5700-3331
Juncheol LeeDepartment of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, Korea.
Hyungoo ShinDepartment of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, Korea.ORCID 0000-0003-3203-1672
Tae-Ho LimDepartment of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, Korea.ORCID 0000-0003-1045-413X
Bo-Hyoung JangDepartment of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.
Youngsuk ChoDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, Korea.ORCID 0000-0002-7648-924X
Wonhee KimDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, Korea.ORCID 0000-0002-7055-2500
Jae-Guk KimDepartment of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, Korea.ORCID 0000-0002-2446-4497
Kyu-Sun ChoiDepartment of Neurosurgery, Hanyang University College of Medicine, Seoul 04763, Korea.
Min-Kyun NaDepartment of Neurosurgery, Hanyang University College of Medicine, Seoul 04763, Korea.ORCID 0000-0001-6826-8490
Chiwon AhnDepartment of Emergency Medicine, College of Medicine, Chung-Ang University, Seoul 06974, Korea.ORCID 0000-0002-1813-1098
Sae-Min KwonDepartment of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 42601, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to evaluate early phase serum albumin levels in and outcomes of resuscitated patients after cardiac arrest. Medline, EMBASE, and the Cochrane Library were systematically searched until 4 July 2022, for studies on post-cardiac arrest patients and involving measurement of early phase albumin levels and assessment of in-hospital mortality or neurologic outcomes. Two reviewers independently assessed the methodological quality of the included studies using the Quality in Prognosis Studies tool. We included 3837 patients from seven observational studies in this systematic review and meta-analysis. The serum albumin level was significantly higher in survivors than in non-survivors, showing a positive association with an overall standardized mean difference (SMD) [(mean value of non-survivors—mean value of survivors)/pooled standard deviation] of 0.55 (95% confidence interval [CI], 0.48−0.62; I2 = 0%; p < 0.001). Additionally, the serum albumin level was significantly higher in the good neurologic outcome group than in the poor neurologic outcome group (four studies; SMD = 1.01, 95% CI = 0.49−1.52, I2 = 87%; p < 0.001). Relatively low serum albumin levels in the early phase may be associated with in-hospital mortality of resuscitated patients after cardiac arrest. However, we could not evaluate the association between albumin level and neurologic outcome because of limited included studies and unresolved high heterogeneity.

Indexed as

albuminheart arrestmeta-analysispatient outcome assessment

Identifiers

PMID36579497
PMCPMC9697792

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.