Evidence map›Paper›PMID 36579479›Full record

ArticleDrug delivery2023

Treatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer.

Ai-Ho Liao, Yu-An Lee, Dao-Lung Lin, Ho-Chiao Chuang, Jehng-Kang Wang, Ching-En Chang, Hsiang-Tzu Li, Ting-Yi Wu, Cheng-Ping Shih, Chih-Hung Wang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Ai-Ho LiaoGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Yu-An LeeGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Dao-Lung LinSpirit Scientific Co., Ltd, Taiwan Branch (Cayman), New Taipei City, Taiwan.
Ho-Chiao ChuangDepartment of Mechanical Engineering, National Taipei University of Technology, Taipei, Taiwan.
Jehng-Kang WangDepartment of Biochemistry, National Defense Medical Center, Taipei, Taiwan.
Ching-En ChangGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Hsiang-Tzu LiGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Ting-Yi WuGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Cheng-Ping ShihDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chih-Hung WangDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Yueng-Hsiang ChuDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
National Defense Medical Center · TWNational Taiwan University of Science and Technology · TWNational Taipei University of Technology · TWTri-Service General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past 50 years, 5-fluorouracil (5-FU) has played a critical role in the systemic chemotherapy of cancer patients. Bolus intravenous (IV) 5-FU infusion has been used due to the limitation of its extremely short half-life (10-15 min). This study used ultrasound (US) mediating 5-FU-loaded microbubbles (MBs) cavitation as a tool to increase local intratumoral 5-FU levels with a reduced dose of 5-FU (a single IV injection of 2.5 mg/kg instead of a single intraperitoneal injection of 25-200 mg/kg as used in previous studies in mice). The 5-FU-MBs were prepared with a 132 mg/mL albumin solution and a 0.30 mg/mL 5-FU solution. The diameters of the MBs and 5-FU-MBs were 1.24 ± 0.85 and 2.00 ± 0.53 µm (mean ± SEM), respectively, and the maximum loading efficiency of 5-FU on MBs was 19.04 ± 0.25%. In the

Indexed as

FluorouracilHead and Neck NeoplasmsAnimalsMiceMicrobubblesTissue DistributionTreatment OutcomeFluorouracil5-fluorouracilcavitationhalf-lifehead nd neck cancerMicrobubblesultrasound

Identifiers

PMID36579479
PMCPMC9809406
OpenAlexW4313332481

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.