Evidence map›Paper›PMID 36579379›Full record

ArticleYonsei medical journal2023

Interactions between Sleep Apnea and Coronary Artery Disease on the Incidence of Sudden Cardiac Arrest: A Multi-Center Case-Control Study.

Eujene Jung, Hyun Ho Ryu, Young Sun Ro, Kyoung Chul Cha, Sang Do Shin, Sung Oh Hwang

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Yonsei medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03700203 (Cardiac Arrest Pursuit Trial With Unique Registration and Epidemiologic Surveillance), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03700203 active not recruitingnot on this map

Cardiac Arrest Pursuit Trial With Unique Registration and Epidemiologic Surveillance

Typeobservational_patient_registrySponsorSeoul National University HospitalRan2017 to 2027Enrolled5,340ConditionsCardiac Arrest, Out-Of-Hospital
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Eujene JungDepartment of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0003-3802-5636
Hyun Ho RyuDepartment of Emergency Medicine, Chonnam National University Hospital, Gwangju, Korea.ORCID https://orcid.org/0000-0002-0276-9994
Young Sun RoDepartment of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0003-3634-9573
Kyoung Chul ChaDepartment of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.ORCID https://orcid.org/0000-0003-1818-2466
Sang Do ShinDepartment of Emergency Medicine, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-4953-2916
Sung Oh HwangDepartment of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.ORCID https://orcid.org/0000-0003-4585-3181

Funding

Korea Disease Control and Prevention Agency 2017E3300601Korea Disease Control and Prevention Agency 2017NE3300600Korea Disease Control and Prevention Agency 2019P330800
6 · The paper itself

Abstract

purposeSleep apnea (SA) is a risk factor for coronary artery disease (CAD), and SA and CAD increase the incidence of sudden cardiac arrest (SCA). This study aimed to investigate the effect of SA on the incidence of SCA and explore the effect of varying degrees of SA with or without CAD on the incidence of SCA. MATERIALS AND

methodsThis prospective multi-center, case-control study was performed using the phase II Cardiac Arrest Pursuit Trial with Unique Registry and Epidemiologic Surveillance (CAPTURES-II) database for SCA cases and community-based controls in Korea. The matching ratio of cases to controls was 1:1, and they were randomly matched within demographics, including age, sex, and residence. The primary variable was a history of SA, and the second variable was a history of CAD. We conducted a conditional logistic regression analysis to estimate the effect of SA and CAD on the SCA risk, and an interaction analysis between SA and CAD.

resultsSA was associated with an increased risk of SCA [adjusted odds ratio (AOR) (95% confidence interval, CI): 1.54 (1.16-2.03)], and CAD was associated with an increased risk of SCA [AOR (95% CI): 3.94 (2.50-6.18)]. SA was a risk factor for SCA in patients without CAD [AOR (95% CI): 1.62 (1.21-2.17)], but not in patients with CAD [AOR (95% CI): 0.56 (0.20-1.53)].

conclusionIn the general population, SA is risk factor for SCA only in patients without CAD. Early medical intervention for SA, especially in populations without pre-existing CAD, may reduce the SCA risk. ClinicalTrials.gov (NCT03700203).

Indexed as

Coronary Artery DiseaseHeart ArrestSleep Apnea SyndromesCase-Control StudiesDeath, Sudden, CardiacHumansIncidenceProspective StudiesRisk Factorscoronary artery diseaserisk factorsSleep apneasudden cardiac arrest

Identifiers

PMID36579379
PMCPMC9826959

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.