Evidence map›Paper›PMID 36579342›Full record

ArticleFrontiers in cellular and infection microbiology2022

An algal lectin griffithsin inhibits Hantaan virus infection

Yajing Zhao, Ningbo Zhao, Yanxing Cai, Hui Zhang, Jia Li, Jiaqi Liu, Chuantao Ye, Yuan Wang, Yamei Dang, Wanying Li and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Yajing ZhaoCollege of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Ningbo ZhaoCollege of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Yanxing CaiGuiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou, China.
Hui ZhangDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Jia LiDepartment of Neurology, Xi'an International Medical Center Hospital, Xi'an, Shaanxi, China.
Jiaqi LiuCollege of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Chuantao YeDepartment of Infectious Diseases, Tangdu Hospital, Airforce Medical University, Xi'an, Shaanxi, China.
Yuan WangDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Yamei DangDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Wanying LiDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
He LiuDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Lianqing ZhangCollege of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Yuexiang LiCollege of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Liang ZhangDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Linfeng ChengDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Yangchao DongDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Zhikai XuDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Yingfeng LeiDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Lu LuKey Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences and BSL-3 Facility, Fudan University, Shanghai, China.
Yingjuan WangCollege of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Wei YeDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Fanglin ZhangDepartment of Microbiology, School of Preclinical Medicine, Airforce Medical University, Xi'an, Shaanxi, China.
Northwest University · CNFudan University · CNYan'an University · CNTang Du Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hantaan virus (HTNV) is the etiological pathogen of hemorrhagic fever with renal syndrome in East Asia. There are currently no effective therapeutics approved for HTNV and other hantavirus infections. We found that griffithsin (GRFT), an algae-derived lectin with broad-spectrum antiviral activity against various enveloped viruses, can inhibit the growth and spread of HTNV.

Indexed as

Hantaan virusHantavirus InfectionsHemorrhagic Fever with Renal SyndromeAnimalsLectinsMicePlant Lectinsgriffithsin protein, GriffithsiaLectinsPlant Lectinsantiviralsgriffithsin (GRFT)Hantaan virushantavirushemorrhagic fever with renal syndrome (HFRS)lectinsuckling micevesicular stomatitis virus (VSV)

Identifiers

PMID36579342
PMCPMC9791197
OpenAlexW4312123507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.