ArticleFrontiers in endocrinology2022
Causal associations of hand grip strength with bone mineral density and fracture risk: A mendelian randomization study.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Trial
- Associations of gait speed, grip strength, depressive symptoms, and their combinations with fracture risk in older adults.GeroScience · 2026Article
- Prevalence and risk factors of CKD-associated osteoporosis in maintenance hemodialysis patients aged over 50 years: a cross-sectional study.Scientific reports · 2026Article
- Article
- Associations of Handgrip Strength with Bone Health and Mental Health in Postmenopausal Women: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- The relationship between osteoporosis and sarcopenia parameters in postmenopausal women under 60 years of age: A cross-sectional study.Irish journal of medical science · 2025Article
- GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.Genome biology · 2025Article
- The association between hand grip strength and chronic kidney disease progression: insights from SMP-CKD studies.International urology and nephrology · 2025Observational
- Serum 25(OH)D Levels in Fragility-Fractured and Non-fractured Patients in a Low Latitude Region.Cureus · 2025Article
- Hand grip strength trajectories and the risk of low bone mineral density in 6-7-year-old children: a prospective study.European journal of pediatrics · 2025Article
- GWAS-Informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.bioRxiv : the preprint server for biology · 2024Article
- The impact of creatine levels on musculoskeletal health in the elderly: a mendelian randomization analysis.BMC musculoskeletal disorders · 2024Article
- Is inflammation a missing link between relative handgrip strength with hyperlipidemia? Evidence from a large population-based study.Lipids in health and disease · 2024Article
- Predictors of Hand Grip Strength in Adults Without Sarcopenia: Data From the NHANES, 2013-2014.Current developments in nutrition · 2024Article
- Association Between Advanced Glycation End Products and Sarcopenia: The Mediating Role of Osteoporosis.The Journal of clinical endocrinology and metabolism · 2024Article
- Hand grip strength and all-cause mortality risk in individuals with decreased bone mass: a study from NHANES database.Frontiers in medicine · 2024Article
- Predicting grip strength-related frailty in middle-aged and older Chinese adults using interpretable machine learning models: a prospective cohort study.Frontiers in public health · 2024Article
- Effects of Frailty Syndrome on Osteoporosis, Focusing on the Mediating Effect of Muscle Strength and Balance in Community-Dwelling Older Adults (≥60 years) in Iran: Results From the Amirkola Health and Aging Project Cohort Study.Geriatric orthopaedic surgery & rehabilitation · 2024Article
- The genetic causal effect of hand grip strength on osteoporosis and falling risk: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Muscle strength has been shown to exert positive effects on bone health. The causal relationship between hand grip strength and osteoporosis is an important public health issue but is not fully revealed. The goal of this study was to investigate whether and to what extent hand grip strength affects bone mineral density (BMD) and fracture risk. Methods: We conducted a state-of-the-art two-sample Mendelian randomization analysis. Genomewide significant ( Results: The results provided strong evidence that hand grip strength trait was causally and positively associated with lumbar spine BMD ( Conclusions: This study showed a positive causal relationship between hand grip strength and lumbar BMD, which is the most common site of osteoporotic fracture, but did not find a causal relationship between hand grip strength and BMD of heel, forearm, or femoral neck. No statistically significant effect of hand grip strength on fracture risk was observed. This study indicates variations in the abilities of hand grip strength trait to causally influence BMD at different skeleton sites. These results should be considered in further studies and public health measures on osteoporosis prevention strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.