Evidence map›Paper›PMID 36578611›Full record

ReviewProceedings (Baylor University. Medical Center)2023

Meta-analysis of the relation between irritable bowel syndrome and antibodies against endogenous gonadotropin-releasing hormone and its receptor.

Karam R Motawea, Joseph Varney, Mohamed Gamal, Kirellos Said Abbas, Fatma A Monib, Mhd Kutaiba Albuni, Elias Battikh, Bisher Sawaf, Lina Taha Khairy, Agyad Bakkour and 6 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Proceedings (Baylor University. Medical Center), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 5 countries.

Karam R MotaweaFaculty of Medicine, Alexandria University, Egypt.
Joseph VarneyAmerican University of the Caribbean School of Medicine, Sint Maarten.
Mohamed GamalFaculty of Medicine, Tanta University, Egypt.
Kirellos Said AbbasFaculty of Medicine, Alexandria University, Egypt.
Fatma A MonibFaculty of Medicine, Assiut University, Egypt.
Mhd Kutaiba AlbuniDepartment of Internal Medicine, Damascus University, Damascus, Syria.
Elias BattikhDepartment of Internal Medicine, Damascus University, Damascus, Syria.
Bisher SawafDepartment of Internal Medicine, Syrian Private University, Damascus, Syria.
Lina Taha KhairyThe National Ribat University, Al-Ribat, Sudan.
Agyad BakkourFaculty of Medicine, Albaath University, Homs, Syria.
Ali Hadi Hussein MuwailiIvano-Frankivsk National Medical University, Ukraine.
Fatima Abubaker Abdalla AbdelmajidUniversity of Medical Sciences and Technology, Sudan.
Eman Mohammed Sharif AhmedNile Vally University, Atbra, Sudan.
Dhuha Hadi Hussein MuwailiIvano-Frankivsk National Medical University, Ukraine.
Safaa M A AhmedFaculty of Medicine, Shendi University, Sudan.
Sarya SwedFaculty of Medicine, Aleppo University, Aleppo, Syria.ORCID https://orcid.org/0000-0002-9983-2020
Alexandria University · EGDamascus University · SYIvano-Frankivsk National Medical University · UAAmerican University of the Caribbean School of Medicine · SXAssiut University · EGHoms University · SYNational Ribat University · SDNile Valley University · SDShendi University · SDSyrian Private University · SYTanta University · EGUniversity of Aleppo · SYUniversity of Medical Sciences and Technology · SD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This meta-analysis assessed the association between gonadotropin hormone-releasing hormone (GnRH) antibodies and irritable bowel syndrome (IBS). We defined a search strategy and implemented it with PubMed, Ovid, Scopus, and Web of Science databases for English language publications. The data were evaluated for acceptability, and randomized controlled studies as well as case-control, cross-sectional, and cohort studies reporting the prevalence of GnRH antibodies in IBS patients were included. The total number of patients in the included studies was 1095: 270 patients in the IBS group and 825 patients in the control group. By comparing the IBS group and the control group, we found a statistically significant association between IBS and the increased prevalence of GnRH IgM antibodies (risk ratio = 2.29, 95% confidence interval = 1.58 to 3.31,

Indexed as

Endogenous gonadotropin-releasing hormoneGnRH antibodiesirritable bowel syndromemetaanalysis

Identifiers

PMID36578611
PMCPMC9762813
OpenAlexW4285086012

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.