Evidence map›Paper›PMID 36578481›Full record

ArticleFrontiers in immunology2022

Fc receptor engagement of HIV-1 Env-specific antibodies in mothers and infants predicts reduced vertical transmission.

Brittani M Barrows, Shelly J Krebs, Ningbo Jian, Michelle Zemil, Bonnie M Slike, Vincent Dussupt, Ursula Tran, Letzibeth Mendez-Rivera, David Chang, Anne Marie O'Sullivan and 16 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Impact ofFrontiers in immunology · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 5 institutions in 2 countries.

Brittani M BarrowsU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Shelly J KrebsU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Ningbo JianU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Michelle ZemilU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Bonnie M SlikeU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Vincent DussuptU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Ursula TranU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Letzibeth Mendez-RiveraU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
David ChangU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Anne Marie O'SullivanU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Brendan MannU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Eric Sanders-BuellU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Zhanna ShubinU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Matt CreeganU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Dominic Paquin-ProulxU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Philip EhrenbergU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Agnes Laurence-ChenineU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Kriengkrai SrithanaviboonchaiDepartment of Community Medicine, Chiang Mai University, Chiang Mai, Thailand.
Rasmi ThomasU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Michael A EllerU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Guido FerrariDepartment of Surgery, Duke University School of Medicine, Durham, NC, United States.
Merlin RobbU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Venigalla RaoDepartment of Biology, The Catholic University of America, Washington, DC, United States.
Sodsai TovanabutraU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Victoria R PolonisU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Lindsay WieczorekU.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, United States.
Henry M. Jackson Foundation · USWalter Reed Army Institute of Research · USCatholic University of America · USChiang Mai University · THDuke University · US

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Potent Phage T4 Derived V2 Immunogens as HIV VaccinesR01AI102725 · NIAID · CATHOLIC UNIVERSITY OF AMERICA · PI RAO, VENIGALLA B. · 2012 to 2015
$1.7M
NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI102725
6 · The paper itself

Abstract

Introduction: Infants acquire maternal antibodies by Fc receptor transcytosis across the placenta during pregnancy. Fc receptors are expressed on immune cells and are important for activation of effector cell functions. Methods: In this study, we evaluated Fc receptor engagement and ADCC activity of plasma binding antibodies from human immunodeficiency virus-1 (HIV) -infected mothers and to identify factors that may contribute to protection from HIV vertical transmission. Results: HIV-specific binding and Fc receptor engagement of plasma antibodies varied between mothers by transmission status and infants by infection status. Non-transmitting (NT) mothers and HIV-uninfected infants had antibodies with higher neonatal Fc receptor (FcRn) and FcγR engagement, as compared to transmitting (T) mothers and HIV+ infants, respectively. A significant inverse correlation between plasma antibody FcRn and FcγR engagement was observed for T mothers, but not NT mothers. Conversely, a significant direct correlation was observed between plasma antibody FcRn and FcγR engagement for HIV- infants, but not for HIV+ infants. Consequently, we observed significantly higher plasma antibody ADCC potency and breadth in HIV- infants, as compared to HIV+ infants. However, no differences in overall ADCC potency and breadth were observed between mothers. FcRn-engagement of HIV-specific antibodies in both mothers and infants predicted a lack of vertical transmission of HIV. Discussion: This study indicates that HIV-uninfected infants acquire HIV-specific antibodies with greater Fc receptor engagement and thus, greater ADCC capacity.

Indexed as

HIV-1HIV InfectionsFemaleHIV AntibodiesHumansInfantInfant, NewbornPregnancyReceptors, FcReceptors, IgGHIV AntibodiesReceptors, FcReceptors, IgGantibody dependent cellular cytotoxicityCRF01_AE HIVneonatal Fc receptorpassive immunitypregnancyprotective immunityThailandvertical transmission

Identifiers

PMID36578481
PMCPMC9791209
OpenAlexW4312123352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.