Evidence map›Paper›PMID 36578326›Full record

ArticleGlobal pediatric health2022

A Comparative Study of Levetiracetam and Phenobarbital for Neonatal Seizures as a First Line Treatment.

Nagwa Elsayed Akeel, Hany Abdelaziz Suliman, Ashraf Hamed Al-Shokary, Asmaa Obada Ibrahim, Naglaa M Kamal, Abobakr Abosree Abdelgalil, Moustafa Kotb Elmala, Hatem Hamed Elshorbagy, Khaled Amin Nasef, Ahmed Mahmoud Attia and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Global pediatric health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07284498 (Treatment of Seizures in Neonate With Hypoxic Ischemic Encephalopathy), which is not on this map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07284498 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Treatment of Seizures in Neonate With Hypoxic Ischemic Encephalopathy

TypeinterventionalSponsorMansoura UniversityRan2026 to 2026Enrolled66ConditionsNeonatal Seizures, HIE - Hypoxic - Ischemic EncephalopathyArmsPhenobarbital, Levetiracetam
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Anti-seizure medications for neonates with seizures.The Cochrane database of systematic reviews · 2023
    Pooled it
  4. Article
  5. Article
  6. Questions and Controversies in Neonatal Seizures.Children (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Nagwa Elsayed AkeelPediatric department, Benha University, Benha, Egypt.
Hany Abdelaziz SulimanPediatric department, Benha University, Benha, Egypt.
Ashraf Hamed Al-ShokaryPediatric department, Benha University, Benha, Egypt.
Asmaa Obada IbrahimPediatric department, Ain Shams University, Cairo, Egypt.
Naglaa M KamalPediatric department, Cairo University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-8535-3838
Abobakr Abosree AbdelgalilPediatric department, Cairo University, Cairo, Egypt.
Moustafa Kotb ElmalaPediatric department, Nizwa Hospital, Nizwa, Sultanate of Oman.
Hatem Hamed ElshorbagyProfessor of Pediatrics and Pediatric Neurology, Faculty of medicine, Menoufia University, Shebeen Elkom, Egypt.ORCID https://orcid.org/0000-0002-2219-3179
Khaled Amin NasefPediatric department, Cairo University, Cairo, Egypt.
Ahmed Mahmoud AttiaPediatric department, Qualiob General Hospital, Qaliob, Egypt.
Mohamed Gamal El Din FathallahPediatric department, Cairo University, Cairo, Egypt.
Cairo University · EGBenha University · EGAin Shams University · EGMenoufia University · EGUniversity of Nizwa · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: We aimed to evaluate the use of intravenous levetiracetam as the first-line treatment of neonatal seizures compared with phenobarbital. Methods: The study was conducted on 104 neonates (0-28 days) with clinical seizures after inclusion criteria. They were assigned in equal ratio into 2 groups; 1 included neonates who received phenobarbitone, and the other included neonates who received levetiracetam. Neonates were loaded with 20 mg/kg of intravenous drug-A (phenobarbitone) or drug-B (levetiracetam). In persistent seizures, a second loading dose of the same drug was given. Crossover to other drugs occurred if seizures persisted after the second dose of the same drug. The proportion of neonates who achieved cessation of seizures following the first or second loading dose of either drug-A or drug-B (PB or LEV) was the main outcome measure provided that they remained free of seizure for the following 24 hours. Results: After 1 or 2 doses of Levetiracatam or Phenobarbitone, clinical seizures stopped (and remained seizure-free for 24 hours) in 41 (78.84%) and 34 (65.38%) patients, respectively ( Conclusion: Levetiracetam is considered an effective and safe drug as a first-line AED in neonatal seizures.

Indexed as

1st lineAntiepileptic drugsmanagementneonateseizure

Identifiers

PMID36578326
PMCPMC9791297
OpenAlexW4312916172

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.