Evidence map›Paper›PMID 36577984›Full record

Trial reportLipids in health and disease2022

Differential effects of bariatric surgery and lifestyle interventions on plasma levels of Lp(a) and fatty acids.

Kirsten A Berk, Heidi Borgeraas, Ingunn Narverud, Monique T Mulder, Linn K L Øyri, Adrie J M Verhoeven, Milada Cvancarova Småstuen, Martin P Bogsrud, Torbjørn Omland, Jens Kristoffer Hertel and 4 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Lipids in health and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00626964 (Prevention of Coronary Heart Disease in Morbidly Obese Patients. Lifestyle Intervention, Low Energy Diet or Bariatric Surgery.), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00626964 active not recruitingnot on this map

Prevention of Coronary Heart Disease in Morbidly Obese Patients. Lifestyle Intervention, Low Energy Diet or Bariatric Surgery.

TypeobservationalSponsorThe Hospital of VestfoldRan2008 to 2026Enrolled200ConditionsMorbid Obesity, Hypertension, Type 2 DM, Obstructive Sleep ApneaArmsBariatric Surgery, Conservative Treatment:
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Low-energy diets before metabolic bariatric surgery: A systematic review of the effect on total body weight, liver volume, glycemia and side effects.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 2 countries.

Kirsten A Berk *Department of Internal Medicine, Division of Pharmacology and Vascular Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Heidi Borgeraas *Morbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway. heibor@siv.no.
Ingunn NarverudNorwegian National Advisory Unit On Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Monique T MulderDepartment of Internal Medicine, Division of Pharmacology and Vascular Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Linn K L ØyriDepartment of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Adrie J M VerhoevenDepartment of Internal Medicine, Division of Pharmacology and Vascular Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Milada Cvancarova SmåstuenMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.
Martin P BogsrudUnit for Cardiac and Cardiovascular Genetics, Oslo University Hospital, Oslo, Norway.
Torbjørn OmlandDepartment of Cardiology, Akershus University Hospital, Lørenskog, Norway.
Jens Kristoffer HertelMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.
Espen GjevestadMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.
Njord NordstrandDepartment of Cardiology, Akershus University Hospital, Lørenskog, Norway.
Kirsten B HolvenNorwegian National Advisory Unit On Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Oslo, Norway.
Jøran HjelmesæthMorbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.
Sykehuset i Vestfold · NOErasmus MC · NLAkershus University Hospital · NOOslo University Hospital · NOUniversity of Oslo · NONorwegian Police University College · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited evidence suggests that surgical and non-surgical obesity treatment differentially influence plasma Lipoprotein (a) [Lp(a)] levels. Further, a novel association between plasma arachidonic acid and Lp(a) has recently been shown, suggesting that fatty acids are a possible target to influence Lp(a). Here, the effects of bariatric surgery and lifestyle interventions on plasma levels of Lp(a) were compared, and it was examined whether the effects were mediated by changes in plasma fatty acid (FA) levels.

methodsThe study includes two independent trials of patients with overweight or obesity. Trial 1: Two-armed intervention study including 82 patients who underwent a 7-week low energy diet (LED), followed by Roux-en-Y gastric bypass and 52-week follow-up (surgery-group), and 77 patients who underwent a 59-week energy restricted diet- and exercise-program (lifestyle-group). Trial 2: A clinical study including 134 patients who underwent a 20-week very-LED/LED (lifestyle-cohort).

resultsIn the surgery-group, Lp(a) levels [median (interquartile range)] tended to increase in the pre-surgical LED-phase [17(7-68)-21(7-81)nmol/L, P = 0.05], but decreased by 48% after surgery [21(7-81)-11(7-56)nmol/L, P < 0.001]. In the lifestyle-group and lifestyle-cohort, Lp(a) increased by 36%[14(7-77)-19(7-94)nmol/L, P < 0.001] and 14%[50(14-160)-57(19-208)nmol/L, P < 0.001], respectively. Changes in Lp(a) were independent of weight loss. Plasma levels of total saturated FAs remained unchanged after surgery, but decreased after lifestyle interventions. Arachidonic acid and total n-3 FAs decreased after surgery, but increased after lifestyle interventions. Plasma FAs did not mediate the effects on Lp(a).

conclusionBariatric surgery reduced, whereas lifestyle interventions increased plasma Lp(a), independent of weight loss. The interventions differentially influenced changes in plasma FAs, but these changes did not mediate changes in Lp(a).

trial registrationTrial 1: Clinicaltrials.gov NCT00626964. Trial 2: Netherlands Trial Register NL2140 (NTR2264).

Indexed as

Bariatric SurgeryObesity, MorbidArachidonic AcidFatty AcidsHumansLife StyleLipoprotein(a)ObesityTreatment OutcomeWeight LossArachidonic AcidFatty AcidsLipoprotein(a)Bariatric surgeryFatty acidsLifestyle interventionLp(a)Obesity

Identifiers

PMID36577984
PMCPMC9795629
OpenAlexW4313417201

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.