Evidence map›Paper›PMID 36577750›Full record

ArticleNature communications2022

Three-dimensional wide-field fluorescence microscopy for transcranial mapping of cortical microcirculation.

Quanyu Zhou, Zhenyue Chen, Yu-Hang Liu, Mohamad El Amki, Chaim Glück, Jeanne Droux, Michael Reiss, Bruno Weber, Susanne Wegener, Daniel Razansky

Abstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Preclinical in-vivo cerebrovascular imaging in rodent models: Methods and applications in Alzheimer's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  3. Review
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  8. Review
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  12. Review
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  16. Article
  17. In vivo three-dimensional brain imaging with chemiluminescence probes in Alzheimer's disease models.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Photoacoustics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Quanyu Zhou *Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0001-7719-4649
Zhenyue Chen *Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Yu-Hang LiuInstitute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Mohamad El AmkiDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
Chaim GlückInstitute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Jeanne DrouxDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
Michael ReissInstitute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Bruno WeberInstitute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zurich, Switzerland.ORCID 0000-0002-9089-0689
Susanne WegenerDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
Daniel RazanskyInstitute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Zurich, Switzerland. daniel.razansky@uzh.ch.ORCID 0000-0001-8676-0964

Funding

Bidirectional optical-acoustic mesoscopic neural interface for image-guided neuromodulation in behaving animalsUF1NS107680 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAZANSKY, DANIEL, RINBERG, DMITRY · 2018 to 2020
$3.4M
High-Resolution Bidirectional Optical-Acoustic Mesoscopic Neural Interface for Image-Guided Neuromodulation in Behaving Animals - RF1 Admin SupplementRF1NS126102 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CAMPBELL, ROBERT E., RAZANSKY, DANIEL · 2022 to 2024
$3.1M
NINDS NIH HHS RF1 NS126102NINDS NIH HHS UF1 NS107680U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) R01-NS126102U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) UF1-NS107680
6 · The paper itself

Abstract

Wide-field fluorescence imaging is an indispensable tool for studying large-scale biodynamics. Limited space-bandwidth product and strong light diffusion make conventional implementations incapable of high-resolution mapping of fluorescence biodistribution in three dimensions. We introduce a volumetric wide-field fluorescence microscopy based on optical astigmatism combined with fluorescence source localization, covering 5.6×5.6×0.6 mm

Indexed as

Ischemic StrokeAnimalsMiceMicrocirculationMicroscopy, FluorescenceSkullTissue Distribution

Identifiers

PMID36577750
PMCPMC9797555

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.