Evidence map›Paper›PMID 36577727›Full record

ArticleAddiction biology2023

GIRK channel activity in prelimbic pyramidal neurons regulates the extinction of cocaine conditioned place preference in male mice.

Timothy R Rose, Ezequiel Marron Fernandez de Velasco, Eric H Mitten, Kevin Wickman

Open access · hybridAbstract read
In one paragraph

Article in Addiction biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Timothy R RoseDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-1473-1739
Ezequiel Marron Fernandez de VelascoDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-0257-4457
Eric H MittenGraduate Program in Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Kevin WickmanDepartment of Pharmacology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-5179-9540
University of Minnesota · US

Funding

Viral Innovation CoreP30DA048742 · NIDA · UNIVERSITY OF MINNESOTA · PI Mark John Thomas · 2020 to 2026
$19.0M
NEUROSCIENCE TRAINING IN DRUG ABUSE RESEARCHT32DA007234 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Paul G Mermelstein, Jocelyn M Richard · 1986 to 2026
$10.9M
Relevance and plasticity of inhibitory metabotropic signaling in reward circuitsR01DA034696 · NIDA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2013 to 2022
$3.4M
Alcohol-related suppression of GIRK channel activity in the basal amygdala: a link to plasticity of glutamatergic neurotransmission and withdrawal-associated behavior?R01AA027544 · NIAAA · UNIVERSITY OF MINNESOTA · PI WICKMAN, KEVIN D · 2020 to 2024
$1.7M
NIAAA NIH HHS R01 AA027544NIDA NIH HHS P30 DA048742NIDA NIH HHS R01 DA034696NIDA NIH HHS T32 DA007234
6 · The paper itself

Abstract

Drug-induced neuroadaptations in the prefrontal cortex (PFC) have been implicated in drug-associated memories that motivate continued drug use. Chronic cocaine exposure increases pyramidal neuron excitability in the prelimbic subregion of the PFC (PL), an adaptation that has been attributed in part to a suppression of inhibitory signalling mediated by the GABA

Indexed as

CocaineAnimalsMaleMicePyramidal CellsSignal TransductionCocainecocaineconditioned place preferenceextinctionGABAB receptorKir3

Identifiers

PMID36577727
PMCPMC10078116
OpenAlexW4309859172

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.