Evidence map›Paper›PMID 36577716›Full record

ArticleEndocrinology, diabetes & metabolism2023

Association between Pro-oxidant-Antioxidant balance and high-sensitivity C-reactive protein in type 2 diabetes mellitus: A Study on Postmenopausal Women.

Hassan Ehteram, Sara Raji, Mina Rahmati, Hanieh Teymoori, Samaneh Safarpour, Nahid Poursharifi, Mona Hashem Zadeh, Reza Pakzad, Hossein Habibi, Naser Mobarra

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Article in Endocrinology, diabetes & metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Hassan EhteramDepartment of Pathology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Sara RajiStudent Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mina RahmatiMetabolic Disorders Research Center, Department of Biochemistry, Golestan University of Medical Sciences, Gorgan, Iran.
Hanieh TeymooriMetabolic Disorders Research Center, Department of Biochemistry, Golestan University of Medical Sciences, Gorgan, Iran.
Samaneh SafarpourDepartment of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Nahid PoursharifiMetabolic Disorders Research Center, Department of Biochemistry, Golestan University of Medical Sciences, Gorgan, Iran.
Mona Hashem ZadehDepartment of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza PakzadDepartment of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran.
Hossein HabibiDepartment of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran.
Naser MobarraDepartment of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0001-7613-8151
Mashhad University of Medical Sciences · IRGolestan University · IRKashan University of Medical Sciences · IRMedical University of Ilam · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOxidative stress known as a predictive marker for cardiovascular and metabolic diseases could be measured through pro-oxidant antioxidant balance (PAB). The present study aimed to evaluate PAB and its association with high-sensitivity C-reactive protein (hs-CRP) in the serum of postmenopausal women with diabetes mellitus.

methodsIn this case-control study, 99 diabetic and 100 healthy postmenopausal women without diabetes mellitus were recruited. Serum PAB values, hs-CRP, lipid profile, insulin, and vitamin D levels were measured. Moreover, insulin resistance (HOMA-IR, HOMA-β and QUICKI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body mass index (BMI) were calculated.

resultsSerum PAB, hs-CRP, insulin resistance, HOMA-β, QUICKI, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) levels were significantly higher in the postmenopausal women with diabetes mellitus, while there was no significant difference in the total cholesterol (TC), serum insulin, WC, WHR, WHtR and vitamin D levels between the groups. Pearson correlation coefficient showed that HDL-C and insulin levels were directly correlated with serum PAB. Also, there was a significant direct relationship between LDL-C and insulin levels and hs-CRP. There was no meaningful relationship between serum insulin and vitamin D levels and other assessed parameters. Backward logistic regression showed a positive relationship between diabetes mellitus and serum PAB and an inverse relationship with serum HDL levels.

conclusionsSerum PAB, hs-CRP concentration, and lipid profile were significantly different between postmenopausal women with and without diabetes mellitus. These differences may contribute to the development of coronary complications.

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceAntioxidantsCase-Control StudiesCholesterol, LDLC-Reactive ProteinFemaleHumansInsulinPostmenopauseReactive Oxygen SpeciesVitamin DAntioxidantsCholesterol, LDLC-Reactive ProteinInsulinReactive Oxygen SpeciesVitamin Ddiabeteshigh-sensitivity C-reactive proteinpost menopausePro-oxidant-antioxidant balancevitamin D

Identifiers

PMID36577716
PMCPMC10000638
OpenAlexW4313277767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.