Evidence map›Paper›PMID 36577656›Full record

ArticleMicrocirculation (New York, N.Y. : 1994)2023

K

Md A Hakim, Erik J Behringer

Open access · hybridAbstract read
In one paragraph

Article in Microcirculation (New York, N.Y. : 1994), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Amyloid β alters vascular CaThe Journal of physiology · 2025
    Article
  2. Review
  3. Article
  4. Review
  5. Vascular Function and Ion Channels in Alzheimer's Disease.Microcirculation (New York, N.Y. : 1994) · 2024
    Review
  6. Review
  7. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Md A HakimBasic Sciences, Loma Linda University, Loma Linda, California, USA.ORCID https://orcid.org/0000-0002-6183-7950
Erik J BehringerBasic Sciences, Loma Linda University, Loma Linda, California, USA.ORCID https://orcid.org/0000-0001-6979-2796
Loma Linda University · US

Funding

Role of Endothelial K+ Channels in Age-Related DementiaR01AG073230 · NIA · LOMA LINDA UNIVERSITY · PI Erik J. Behringer, Paulo W Pires · 2022 to 2026
$3.3M
Cerebrovascular Endothelial Function in Aging and Alzheimer's DiseaseR56AG062169 · NIA · LOMA LINDA UNIVERSITY · PI BEHRINGER, ERIK J. · 2018 to 2018
$391k
NIA NIH HHS R01 AG073230NIA NIH HHS R56 AG062169NIH HHS 1R01AG073230NIH HHS 1R56AG062169
6 · The paper itself

Abstract

objectiveEndothelial cell (EC) coupling occurs through gap junctions and underlies cerebral blood flow regulation governed by inward-rectifying K

methodsIntact EC tubes (width: ~90-100 μm; length: ~0.5 mm) were freshly isolated from posterior cerebral arteries of young Pre-AD (1-3 months) and aged AD (13-18 months) male and female 3xTg-AD mice. Dual intracellular microelectrodes applied simultaneous current injections (±0.5-3 nA) and membrane potential (V

resultsConducted V

conclusionsBrain endothelial K

Indexed as

Alzheimer DiseaseAnimalsEndothelial CellsEndothelium, VascularFemaleGap JunctionsMaleMembrane PotentialsMiceAlzheimer's diseaseBrain endotheliumelectrical conductionendothelial cell couplingK+ ion channels

Identifiers

PMID36577656
PMCPMC9885900
OpenAlexW4313221244

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.