Evidence map›Paper›PMID 36577387›Full record

ArticleCell reports2022

Brain capillary pericytes are metabolic sentinels that control blood flow through a K

Ashwini Hariharan, Colin D Robertson, Daniela C G Garcia, Thomas A Longden

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. KFrontiers in neurology · 2024
    Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Pericyte KNature cardiovascular research · 2026
    Article
  8. Article
  9. A balancing act keeps the brain fed.Nature cardiovascular research · 2026
    Article
  10. Article
  11. Review
  12. A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Rediscovery of pericytes within the neurovascular unit for cerebral ischemia/reperfusion injury.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  14. Chemogenetic modulation of CNS pericytes: Impact on pericyte CaMolecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  15. Cerebral capillary computation.American journal of physiology. Cell physiology · 2026
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ashwini HariharanDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA; Laboratory of Neurovascular Interactions, Center for Biomedical Engineering and Technology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Colin D RobertsonDepartment of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Daniela C G GarciaDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA; Laboratory of Neurovascular Interactions, Center for Biomedical Engineering and Technology, School of Medicine, University of Maryland, Baltimore, MD, USA.
Thomas A LongdenDepartment of Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA; Laboratory of Neurovascular Interactions, Center for Biomedical Engineering and Technology, School of Medicine, University of Maryland, Baltimore, MD, USA. Electronic address: thomas.longden@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

Investigating the Microvascular Mechanisms of O2 Supply-Demand Mismatch in Small Vessel Disease using Novel High-Resolution Optical ImagingR01NS115401 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI AYATA, CENK, SAKADZIC, SAVA · 2020 to 2024
$3.5M
Pericytes as metabolic sentinels in the control of brain blood flow in health and Alzheimer's diseaseR01AG066645 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI Thomas A Longden · 2020 to 2026
$2.5M
Vascular Signaling Plasticity - Novel Concepts and Tools for Studying Neurovascular Interactions in Health and DiseaseDP2NS121347 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI LONGDEN, THOMAS A · 2020 to 2020
$2.3M
Advanced components for an existing spinning disk confocal in an established core imaging facilityS10OD026698 · OD · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2019 to 2019
$274k
American Heart Association-American Stroke Association 830093NIA NIH HHS R01 AG066645NIH HHS S10 OD026698NINDS NIH HHS DP2 NS121347NINDS NIH HHS R01 NS115401
6 · The paper itself

Abstract

Despite the abundance of capillary thin-strand pericytes and their proximity to neurons and glia, little is known of the contributions of these cells to the control of brain hemodynamics. We demonstrate that the pharmacological activation of thin-strand pericyte K

Indexed as

CapillariesPericytesAdenosine TriphosphateBrainHemodynamicsAdenosine Triphosphatecapillariescerebral blood flowCP: Neuroscienceendothelial cellsenergyfunctional hyperemiaglucoseKATP channelsK(IR) channelsmetabolismneurovascular couplingpericytes

Identifiers

PMID36577387
PMCPMC10187957
OpenAlexW4313255101

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.