Evidence map›Paper›PMID 36577368›Full record

ArticleCell reports2022

A circadian clock translational control mechanism targets specific mRNAs to cytoplasmic messenger ribonucleoprotein granules.

Kathrina D Castillo, Cheng Wu, Zhaolan Ding, Osiris K Lopez-Garcia, Emma Rowlinson, Matthew S Sachs, Deborah Bell-Pedersen

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  5. Article
  6. Rhythmic Dynamics of Stress Granules inInternational journal of molecular sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kathrina D CastilloCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA.
Cheng WuDepartment of Biology, Texas A&M University, College Station, TX 77843, USA.
Zhaolan DingCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA.
Osiris K Lopez-GarciaDepartment of Biology, Texas A&M University, College Station, TX 77843, USA.
Emma RowlinsonDepartment of Biology, Texas A&M University, College Station, TX 77843, USA.
Matthew S SachsDepartment of Biology, Texas A&M University, College Station, TX 77843, USA.
Deborah Bell-PedersenCenter for Biological Clocks Research, Texas A&M University, College Station, TX 77843, USA; Department of Biology, Texas A&M University, College Station, TX 77843, USA. Electronic address: dpedersen@tamu.edu.
Texas A&M University · US

Funding

Mechanisms of Circadian Clock Control of mRNA TranslationR35GM126966 · NIGMS · TEXAS A&M UNIVERSITY · PI Deborah Bell-Pedersen · 2018 to 2026
$6.6M
IMSD at Texas A&M University: Initiative for Maximizing Student Diversity in Biomedical SciencesT32GM135748 · NIGMS · TEXAS A&M UNIVERSITY · PI BRINKMEYER-LANGFORD, CANDICE L., CHIU, WEIHSUEH A · 2020 to 2024
$1.2M
NIGMS NIH HHS R35 GM126966NIGMS NIH HHS T32 GM135748
6 · The paper itself

Abstract

Phosphorylation of Neurospora crassa eukaryotic initiation factor 2 α (eIF2α), a conserved translation initiation factor, is clock controlled. To determine the impact of rhythmic eIF2α phosphorylation on translation, we performed temporal ribosome profiling and RNA sequencing (RNA-seq) in wild-type (WT), clock mutant Δfrq, eIF2α kinase mutant Δcpc-3, and constitutively active cpc-3

Indexed as

Circadian ClocksCytoplasmic GranulesEukaryotic Initiation Factor-2PhosphorylationProtein BiosynthesisProtein Processing, Post-TranslationalRibonucleoproteinsRNA, MessengerEukaryotic Initiation Factor-2messenger ribonucleoproteinRibonucleoproteinsRNA, Messengercircadian clockCPC-3CP: Molecular biologycytoplasmic messenger ribonucleoprotein granuleseIF2αGCN2Neurospora crassaP-bodyribosome profilingtranslation control

Identifiers

PMID36577368
PMCPMC10241597
OpenAlexW4313254439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.