Evidence map›Paper›PMID 36577367›Full record

ArticleCell reports2022

Mitochondrial genome recovery by ATFS-1 is essential for development after starvation.

Nandhitha Uma Naresh, Sookyung Kim, Tomer Shpilka, Qiyuan Yang, Yunguang Du, Cole M Haynes

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nandhitha Uma NareshDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Sookyung KimDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Tomer ShpilkaDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Qiyuan YangDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Yunguang DuDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Cole M HaynesDepartment of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA. Electronic address: cole.haynes@umassmed.edu.
University of Massachusetts Chan Medical School · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Coordinated Repair and Regeneration of Defective MitochondriaR37AG047182 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Cole M Haynes · 2020 to 2026
$3.2M
Coordinating mitochondrial network expansion and longevity via the Integrated Stress Response (ISR)R56AG075204 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HAYNES, COLE M · 2022 to 2022
$335k
Modulation of mitochondrial biogenesis by the Integrated Stress Response (ISR)F30AG077833 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Sookyung Kim · 2022 to 2026
$215k
NIA NIH HHS F30 AG077833NIA NIH HHS R37 AG047182NIA NIH HHS R56 AG075204NIH HHS P40 OD010440
6 · The paper itself

Abstract

Nutrient availability regulates the C. elegans life cycle as well as mitochondrial physiology. Food deprivation significantly reduces mitochondrial genome (mtDNA) numbers and leads to aging-related phenotypes. Here we show that the bZIP (basic leucine zipper) protein ATFS-1, a mediator of the mitochondrial unfolded protein response (UPR

Indexed as

Caenorhabditis elegans ProteinsGenome, MitochondrialAnimalsCaenorhabditis elegansDNA, MitochondrialMitochondriaUnfolded Protein ResponseCaenorhabditis elegans ProteinsDNA, MitochondrialATFS-1C. elegansCP: MetabolismCP: Molecular biologyDAF-2insulin receptormitochondriamtDNAstarvationstress responseUPRUPRmt

Identifiers

PMID36577367
PMCPMC9922093
OpenAlexW4313254260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.