ArticleInternational journal of hygiene and environmental health2023
Inflammatory profiles, gut microbiome, and kidney function are impacted after high-fidelity firefighter training.
Article in International journal of hygiene and environmental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Occupational heat exposure and chronic kidney disease risk under climate warming: a retrospective cohort study of petrochemical workers with mechanistic insights.Environmental health : a global access science source · 2026Article
- Nasal cavity microbial makeup and the influence on psychiatric symptoms following fire exposure in firefighters.Frontiers in microbiomes · 2026Article
- Hydration Considerations to Improve the Physical Performance and Health of Firefighters.Journal of functional morphology and kinesiology · 2024Review
- Alteration of gut microbiota after heat acclimation may reduce organ damage by regulating immune factors during heat stress.Frontiers in microbiology · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundFirefighters are frequently exposed to high temperatures, environmental toxicants, and strenuous physical demands. The health impacts of these occupational exposures on processes including inflammation and kidney function as well as on the gut microbiota are poorly understood. A firefighter training course may provide a controlled environment to assess these health risks.
methodsBasic health measures, stool, and blood samples were obtained from 24 firefighters participating in a one-week, heat-intensive training course. Indicators of inflammation, gut permeability, kidney health, and stool microbiota composition were measured before and after the training course in 18 participants. Urine specific gravity was measured before and after a heat-intensive training day to evaluate dehydration.
resultsThe majority of firefighters in this cohort were categorized as hypertensive and experienced multiple heat-related illness symptoms during the training week and dehydration after the heat-intensive training day. While plasma IL-1β, CXCL8, and NGAL decreased over the training week, other indicators of inflammation and acute kidney injury increased, and estimated kidney function declined. Microbiota composition shifted over the course of the training week, with changes in Peptostreptococcus anaerobius and Streptococcus.
conclusionsThis pilot study conducted in a controlled field setting suggests that the occupational environment of firefighters may increase their risk for systemic inflammation and kidney disease.
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Registered trials
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