Evidence map›Paper›PMID 36577071›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Ultrafast spectra and kinetics of human green-cone visual pigment at room temperature.

Dinesh Dhankhar, David Salom, Krzysztof Palczewski, Peter M Rentzepis

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Ultrafast transient absorption spectra and kinetics of human blue cone visual pigment at room temperature.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Glu102Biochemistry · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dinesh DhankharDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843.ORCID 0000-0002-3178-3058
David SalomDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697.
Krzysztof PalczewskiDepartment of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697.ORCID 0000-0002-0788-545X
Peter M RentzepisDepartment of Electrical and Computer Engineering, Texas A&M University, College Station, TX 77843.ORCID 0000-0003-4182-2409
Texas A&M University · USUniversity of California, Irvine · US

Funding

The complex role of phosphodiesterase 6 in rod photoreceptor health and functionR01EY030873 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Krzysztof Palczewski · 2020 to 2026
$3.5M
NEI NIH HHS R01 EY030873
6 · The paper itself

Abstract

Rhodopsin is the pigment that enables night vision, whereas cone opsins are the pigments responsible for color vision in bright-light conditions. Despite their importance for vision, cone opsins are poorly characterized at the molecular level compared to rhodopsin. Spectra and kinetics of the intermediate states of human green-cone visual pigment (mid-wavelength sensitive, or MWS opsin) were measured and compared with the intermediates and kinetics of bovine rhodopsin. All the major intermediates of the MWS opsin were recorded in the picosecond to millisecond time range. Several intermediates in MWS opsin appear to have characteristics similar to the intermediates of bovine rhodopsin; however, there are some marked differences. One of the most striking differences is in their kinetics, where the kinetics of the MWS opsin intermediates are slower compared to those of the bovine rhodopsin intermediates.

Indexed as

Color VisionCone OpsinsAnimalsCattleHumansKineticsOpsinsRetinal Cone Photoreceptor CellsRhodopsinRod OpsinsTemperatureCone OpsinsOpsinsRhodopsinRod Opsins11-cis-retinalgreen cone-opsinsphototransductionrhodopsinvisual cycle

Identifiers

PMID36577071
PMCPMC9910472
OpenAlexW4313224678

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.