Evidence map›Paper›PMID 36576777›Full record

ArticleeLife2022

Mature parvalbumin interneuron function in prefrontal cortex requires activity during a postnatal sensitive period.

Sarah E Canetta, Emma S Holt, Laura J Benoit, Eric Teboul, Gabriella M Sahyoun, R Todd Ogden, Alexander Z Harris, Christoph Kellendonk

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Parvalbumin interneurons under stress: converging mechanisms of vulnerability.The international journal of neuropsychopharmacology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Aperiodic Signatures of Stress Sensitivity and Depression Recurrence in Adolescents.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026
    Article
  7. Review
  8. Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  9. Review
  10. Prefrontal cortex development and its implications in mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Interneuron Diversity: How Form Becomes Function.Cold Spring Harbor perspectives in biology · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Adolescent Alcohol Exposure Dysregulates Developing Cortical GABA Circuits.Advances in experimental medicine and biology · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sarah E CanettaDepartment of Psychiatry, Columbia University Medical Center, New York, United States.ORCID 0000-0002-3860-2504
Emma S HoltDivision of Developmental Neuroscience, New York State Psychiatric Institute, New York, United States.
Laura J BenoitDepartment of Psychiatry, Columbia University Medical Center, New York, United States.
Eric TeboulDivision of Molecular Therapeutics, New York Psychiatric Institute, New York, United States.
Gabriella M SahyounDivision of Developmental Neuroscience, New York State Psychiatric Institute, New York, United States.
R Todd OgdenDepartment of Biostatistics, Mailman School of Public Health, Columbia University Medical Center, New York, United States.
Alexander Z HarrisDepartment of Psychiatry, Columbia University Medical Center, New York, United States.ORCID 0000-0001-9089-0366
Christoph KellendonkDepartment of Psychiatry, Columbia University Medical Center, New York, United States.ORCID 0000-0003-3302-2188
Columbia University Irving Medical Center · USNew York Psychoanalytic Society and Institute · US

Funding

Sensitive periods for interneuron development supporting cognitive flexibilityR01MH128277 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI SARAH E CANETTA · 2022 to 2026
$2.8M
VTA-nucleus accumbens circuit dynamics underlying stress susceptibilityK08MH109735 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HARRIS, ALEXANDER · 2017 to 2020
$793k
Effects of maternal immune activation on offspring GABA circuitry and behaviorK01MH107760 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI CANETTA, SARAH E · 2016 to 2019
$732k
An adolescent sensitive period for thalamo-prefrontal circuit maturationR21MH121334 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2020 to 2021
$446k
Thalamo-Prefrontal interactions in cognition: cortical layersR21MH117454 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2018 to 2019
$428k
The effect of adolescent thalamic inhibition on adult prefrontal cortical functionF31MH119691 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENOIT, LAURA JACQUELINE · 2019 to 2022
$203k
NIMH NIH HHS F31 MH119691NIMH NIH HHS K01 MH107760NIMH NIH HHS K08 MH109735NIMH NIH HHS R01 MH128277NIMH NIH HHS R21 MH117454NIMH NIH HHS R21 MH121334
6 · The paper itself

Abstract

In their seminal findings, Hubel and Wiesel identified sensitive periods in which experience can exert lasting effects on adult visual cortical functioning and behavior via transient changes in neuronal activity during development. Whether comparable sensitive periods exist for non-sensory cortices, such as the prefrontal cortex, in which alterations in activity determine adult circuit function and behavior is still an active area of research. Here, using mice we demonstrate that inhibition of prefrontal parvalbumin (PV)-expressing interneurons during the juvenile and adolescent period, results in

Indexed as

InterneuronsParvalbuminsAnimalsMiceNeuronsPrefrontal CortexParvalbuminscognitive flexibilitydevelopmentgamma oscillationsinterneuronsmouseneuroscienceparvalbuminprefrontal cortex

Identifiers

PMID36576777
PMCPMC9797185
OpenAlexW4312225738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.