Evidence map›Paper›PMID 36576242›Full record

ArticleTissue barriers2023

Antenatal Ureaplasma infection induces ovine small intestinal goblet cell defects: a strong link with NEC pathology.

Charlotte van Gorp, Ilse H de Lange, Matthias C Hütten, Carmen López-Iglesias, Kimberly Ri Massy, Lilian Kessels, Boris Kramer, Willine van de Wetering, Brad Spiller, George M Birchenough and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Tissue barriers, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. AntenatalInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Charlotte van GorpDepartment of Pediatrics, School of Oncology and Reproduction (GROW), Maastricht University, Maastricht, The Netherlands.
Ilse H de LangeDepartment of Pediatrics, School of Oncology and Reproduction (GROW), Maastricht University, Maastricht, The Netherlands.
Matthias C HüttenDepartment of Pediatrics, School of Oncology and Reproduction (GROW), Maastricht University, Maastricht, The Netherlands.
Carmen López-IglesiasMicroscopy CORE Lab, Maastricht Multimodal Molecular Imaging Institute (M4I), Maastricht University, Maastricht, The Netherlands.
Kimberly Ri MassyDepartment of Pediatrics, School of Oncology and Reproduction (GROW), Maastricht University, Maastricht, The Netherlands.
Lilian KesselsDepartment of Pediatrics, School of Oncology and Reproduction (GROW), Maastricht University, Maastricht, The Netherlands.
Boris KramerDepartment of Pediatrics, School of Oncology and Reproduction (GROW), Maastricht University, Maastricht, The Netherlands.
Willine van de WeteringMicroscopy CORE Lab, Maastricht Multimodal Molecular Imaging Institute (M4I), Maastricht University, Maastricht, The Netherlands.
Brad SpillerDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
George M BirchenoughDepartment of Medical Biochemistry, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.
Wim G van GemertDepartment of Surgery, School for Nutrition, Toxicology and Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands.
Luc J ZimmermannDepartment of Pediatrics, School of Oncology and Reproduction (GROW), Maastricht University, Maastricht, The Netherlands.
Tim Gam WolfsDepartment of Pediatrics, School of Oncology and Reproduction (GROW), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0003-4417-4144
Maastricht University · NLCardiff University · GBUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disruption of the intestinal mucus barrier and intestinal epithelial endoplasmic reticulum (ER) stress contribute to necrotizing enterocolitis (NEC). Previously, we observed intestinal goblet cell loss and increased intestinal epithelial ER stress following chorioamnionitis. Here, we investigated how chorioamnionitis affects goblet cells by assessing their cellular characteristics. Importantly, goblet cell features are compared with those in clinical NEC biopsies. Mucus thickness was assessed as read-out of goblet cell function. Fetal lambs were intra-amniotically (IA) infected for 7d at 122 gestational age with

Indexed as

ChorioamnionitisUreaplasma InfectionsAnimalsFemaleGoblet CellsHumansIntestinal MucosaMucusPregnancySheepChorioamnionitisER stressgoblet cellmucusNECTEM

Identifiers

PMID36576242
PMCPMC10606782
OpenAlexW4313224724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.